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F18 DCFPyL PET/CT in Imaging Participants With Recurrent Prostate Cancer
Not Recruiting
Trial ID: NCT03501940
Purpose
This study provides fluorine F 18 DCFPyL positron emission tomography/computed tomography
(PET/CT) to participants with prostate cancer that has come back. Diagnostic procedures, such
as fluorine F 18 DCFPyL PET/CT, may help find and diagnose prostate cancer and find out how
far the disease has spread.
Official Title
18F-DCFPyL PET/CT in the Evaluation of Patients With Biochemical Recurrence of Prostate Cancer and Non-Contributory CT Scans
Stanford Investigator(s)
Andrei Iagaru
Professor of Radiology (Nuclear Medicine)
Eligibility
Inclusion Criteria:
- Biopsy proven prostate adenocarcinoma
- Rising PSA after definitive therapy with prostatectomy or radiation therapy (external
beam or brachytherapy)
- Post radical prostatectomy (RP) - American Urological Association (AUA)
recommendation
- PSA greater than 0.2 ng/mL measured after at least 6 weeks from radical
prostatectomy
- Confirmatory persistent PSA greater than 0.2 ng/mL (total of two PSA
measurements greater than 0.2 ng/mL)
- Post-radiation therapy - American Society for Radiation Oncology (ASTRO) -
Phoenix consensus definition
- A rise of PSA measurement of 2 or more ng/mL over the nadir
- Able to provide written consent
- Karnofsky performance status of > 50 (or Eastern Cooperative Oncology Group [ECOG] /
World Health Organization [WHO] equivalent)
Exclusion Criteria:
- Unable to provide informed consent
- Inability to lie still for the entire imaging time
- Inability to complete the needed investigational and standard-of-care imaging
examinations due to other reasons (severe claustrophobia, radiation phobia, etc.)
- Any additional medical condition, serious intercurrent illness, or other extenuating
circumstance that, in the opinion of the Investigator, may significantly interfere
with study compliance
Intervention(s):
procedure: Computed Tomography
radiation: Fluorine F 18 DCFPyL
other: Laboratory Biomarker Analysis
procedure: Positron Emission Tomography
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Pranav Hegde
650-721-4080