Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)

Inclusion Criteria:

Patients fulfilling the inclusion criteria will be eligible for enrollment in this study.
Of those who consent, only patients who lack a suitable HLA-identical or 1 allele or
antigen mismatched related donors are evaluable. Patients with an HLA-identical sibling or
1 allele or antigen mismatched family member donor are evaluable as long as the center
deems the family member donor as unsuitable for other reasons. Patients may co-enroll with
other interventional or observational studies.

   1. Patients of all ages with AML, ALL, MDS, NHL, HL, AA, or SCD are eligible.

   2. Any planned conditioning regimen and GVHD prophylaxis approach is eligible.

   3. Patients must be considered suitable allogeneic transplant candidates at the time of
   enrollment based on medical history, physical examination, and available laboratory
   tests. Specific testing for organ function is not required for eligibility but, if
   available, these tests should be used by the treating physician to judge transplant
   suitability.

   4. Patient and physician must intend to proceed with allogeneic HCT within the next 6
   months if a suitable donor is identified.

   5. Center plans to follow the algorithm for alternative donor identification: (a) for
   subjects who are Very Likely to find a MUD, attempt to identify a matched unrelated
   donor; (b) for a subjects who are Very Unlikely to find a MUD, proceed expeditiously
   to a haploidentical, cord blood or mismatched unrelated donor.

   6. Signed informed consent, and assent if applicable. Consent may be signed prior to
   completion of family typing but patients will only be considered evaluable upon
   confirmation that there is no suitable HLA-identical or 1 allele or antigen mismatched
   related donor available.

Exclusion Criteria:

   1. Prior allogeneic HCT (prior autologous transplant is allowed)

   2. Previous formal unrelated donor search