Trial Search Results

Predicting Endometrial Receptivity for Optimal Reproductive Management

The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for endometriosis and predicting implantation and pregnancy rate after embryo transfer.

This study design will provide for the first time, an opportunity to compare endometrial biopsy material from hyperstimulated (gonadotropin treated) subjects after egg retrieval. If successful, it would provide a new protocol for women with unexplained infertility or those with known endometriosis to avoid poor IVF outcomes.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Stanford Investigator(s):


  • Procedure: Endometrial Biopsy
  • Other: Euploid embryo transfer
  • Diagnostic Test: Blood sample


Inclusion Criteria:

   1. Age - 18 to 42

   2. Parity - G0 or greater

   3. AMH ≥ 1 and ≤ 5

   4. Meets criteria for assignment into 1 of the 3 groups

   5. Planning to undergo IVF with delayed embryo transfer

   6. Must have blastocyst(s) by day 6 that were biopsied for PGT-A

   7. Willing to sign consent for endometrial biopsy and collection of blood

   8. Endometrial thickness at time of hCG ≥ 6 and ≤ 14

Exclusion Criteria:

   1. Uterine fibroids > 4 cm in size

   2. Polycystic ovary syndrome (PCOS) according with the Rotterdam criteria.

   3. Ovarian failure and subjects receiving donor oocytes/embryos

   4. Failure to identify at least 1 euploid embryo for FET

   5. Anti-cardiolipid and/or lupus anti-coagulant abnormalities by history

   6. Diabetes mellitus (Type I or Type II)

   7. Untreated hypothyroidism

   8. Hyperprolactinemia

   9. BMI ≤ 17 and ≥ 35

10. Uncorrected uterine anomaly

Ages Eligible for Study

18 Years - 42 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Raquel Fleischmann, DVM
Not Recruiting