Trial Search Results

Effects of an Intermittent Reduced Calorie Diet on Crohn's Disease

The purpose of this study is to see how an Intermittent Calorie Reduced Diet (IRCD) that mimics fasting effects inflammation in patients with mild to moderate Crohn's disease (CD). The diet may allow users to receive the benefits of fasting while also being able to enjoy food (the ingredients of which are GRAS (generally recognized as safe) by the Food and Drug Administration (FDA). Research on dietary interventions and CD are very limited. Diets that mimick fasting have been studied with support of the National Institute of Health and published in leading journals. This research investigates whether markers of inflammation decrease and/or quality of life increases after five-day periods of the IRCD, and may provide rationale for its use to treat CD.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):


  • Other: Intermittent Reduced Calorie Diet (IRCD)




Inclusion Criteria:

   - Mild to moderate Crohn's disease (CDAI score 150-450)

   - Between the ages of 18-70

   - Elevated stool calprotectin and/or serum inflammatory marker levels (ESR and/or CRP)

Exclusion Criteria:

   - Women who are pregnant, nursing or expect to be pregnant

   - Individuals allergic to nuts

   - Individuals with a body mass index (BMI) lower than 18

   - Individuals diagnosed with a serious medical condition (unless approved in writing by
   a physician)

   - Individuals who have been severely weakened by a disease or medical procedure

   - Individuals who are taking medication which may not be safely consumed with a calorie
   restricted diet

   - Individuals with diabetes who are taking anti-diabetic drugs associated with risk of

   - Individuals with more than mild-moderate cardiovascular disease or life-threatening
   cancer (as determined by patient's physician) unless approved by a physician

   - Individuals with history of severe cardiac disease (particularly uncompensated
   congestive heart failure NYHA grade 2 or more or LVEF < 40%)

   - Individuals with a history of syncope

   - Individuals with dietary needs incompatible with the IRCD meal plan

   - Individuals with liver or kidney disorders that may be affected by very low glucose
   and protein content of the diet

   - Patients on a calorie restricted diet will also be excluded

Ages Eligible for Study

18 Years - 70 Years

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Karolin Jarr, MD