DCM Precision Medicine Study

Inclusion Criteria:

   - Meeting criteria for dilated cardiomyopathy (DCM) :

      - Left ventricular ejection fraction <50%

      - Left ventricular enlargement (A left ventricular end-diastolic dimension >
      95%tile population standard based on gender and height).

   - Detectable causes of cardiomyopathy, except genetic, excluded beyond a reasonable
   doubt at the time of DCM diagnosis (that is, meeting clinical criteria for idiopathic
   DCM)

   - Any age (including children)

   - Non-Hispanic and Hispanic ethnicity

   - All races (PI pre-approval required for recruitment beyond pre-specified recruitment
   targets).

   - Ability to give informed consent

   - Ability to communicate in English (except Spanish language at sites approved to
   recruit individuals of Hispanic ethnicity)

   - Willingness to participate in a family-based study (patient willing to work with a
   clinical site and/or OSU to facilitate the recruitment and enrollment of family
   members to the study).

Exclusion Criteria:

   - Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any
   major epicardial coronary artery)

   - Primary valvular disease

   - Adriamycin or other cardiotoxic drug exposure

   - Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right
   Ventricular Dysplasia/Cardiomyopathy

   - Congenital heart disease

   - Other detectable causes of dilated cardiomyopathy, including sarcoid and
   hemochromatosis.

   - Other active multi-system disease that may cause DCM (e.g., active connective tissue
   disease).

   - Severe and untreated or untreatable hypertension (systolic blood pressures routinely
   greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if
   resistant to multidrug treatment).

   - However, conventional risk factors for DCM, including obesity, routinely treated
   hypertension, alcohol use, pregnancy or the peri-partum period, or left ventricular
   noncompaction, will NOT be considered exclusion criteria.