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Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Recruiting
I'm InterestedTrial ID: NCT03507218
Purpose
Background:
PANS is an illness that comes on suddenly in children. The full name is Pediatric Acute-Onset
Neuropsychiatric Syndrome. It can cause sudden obsessive-compulsive behaviors. It can also
cause children to suddenly restricte their food intake. Researchers want to learn more about
children with PANS. They also want to learn more about the illness.
Objective:
To study some disorders of behavior and emotion that start in childhood.
Eligibility:
Children 3 14 years old who have had severe obsessive-compulsive symptoms or food restriction
start quickly
Design:
Parents will answer questions. The topics include:
Their child s medical history
Their child s physical and mental health
Their family history. The focus will be on neurodevelopmental and psychiatric conditions. A
family tree will be drawn.
Participants will have a physical exam.
Participants may take tests on paper or computer. These will focus on thinking, memory, and
behavior.
Participants and parents will give a blood sample.
Participants will have magnetic resonance imaging (MRI). A strong magnetic field and radio
waves take pictures of the brain. Participants will lie on a table that slides in and out of
a metal scanner.
Participants may have photos or videos taken.
Participants may have other tests. These may include heart tests, sleep tests, and lumbar
puncture.
Sponsoring Institute: National Institute of Mental Health
Official Title
Clinical, Laboratory, and Biomedical Characterization of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Eligibility
- INCLUSION CRITERIA:
Affected Probands (Children with PANS) will be eligible if they:
1. Are 3 to 14 years of age (initial enrollment must occur prior
2. Have a history of abrupt onset (less than 24-48 hours) of impairing OCD and/or eating
restrictions.
3. Are able to travel safely to the regional medical center where the evaluations will be
conducted and are able to be examined safely over a period of one or more days.
4. Assent to participate (if they are at least seven years old and have capacity to do
so) and have legal guardians who consent to their minor child s participation.
5. Are under the care of a primary physician in their home community.
First-degree Relatives will be eligible if they:
1. Are a biologic parent or sibling of an affected proband.
2. Consent (or assent) to undergo study evaluations and to provide blood, microbial and
genetic samples.
Children with Non-PANS Neuropsychiatric Symptoms may be enrolled if they:
1. Are 3 to 14 years of age (initial enrollment must occur prior to the participant s
15th birthday to permit prospective longitudinal evaluations)
2. Have OCD, tics, anxiety disorders, or other psychiatric symptoms, but do NOT have a
history of acute symptom onset.
3. Are willing to participate in medical, psychiatric, and behavioral assessments and to
provide bio-specimens including blood, urine, and microbial flora (mouth, oropharynx,
and/or stool).
4. Assent to participate (if they are at least seven years old and have capacity to do
so) and have legal guardians who consent to their minor child s participation.
5. Are under the care of a primary physician in their home community.
Healthy Pediatric Volunteers may be enrolled if they:
1. Are 3 to 14 years of age (initial enrollment must occur prior to the participant s
15th birthday to permit prospective longitudinal evaluations).
2. Are physically healthy and do not have psychiatric symptoms.
3. Are willing to participate in medical, psychiatric, and behavioral assessments and to
provide bio-specimens including blood, urine, and microbial flora (mouth, oropharynx,
and/or stool).
4. Assent to participate (if they are at least seven years old and have capacity to do
so) and have legal guardians who consent to their minor child s participation.
EXCLUSION CRITERIA:
Participants will not be eligible if they:
1. Appear to the investigators to be too unstable psychiatrically or medically to
participate safely in the protocol.
2. Are unwilling or unable to be evaluated and followed prospectively.
3. Have a parent/guardian who is not willing to participate at a distance through
web-based or phone-based data collection.
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305