A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors

Inclusion Criteria:

   - The participants ages are < 18 for part 1a, < 30 for Parts 1b. 2 and 3

   - Study Part 1 (single-agent therapy dose escalation): histologically confirmed
   diagnosis of neuroblastoma or other solid tumor that has progressed or recurred
   despite standard therapy, and for which there is no therapy proven to prolong survival
   with an acceptable quality of life

   - Study Part 1 (combination safety run-in), Study Part 2 (initial expansion), and Study
   Part 3 (additional expansion): histologically confirmed diagnosis of neuroblastoma,
   AML, or precursor-B ALL that has progressed or recurred despite, or is refractory to,
   standard therapy

   - Adequate performance status: Participants <16 years of age: Lansky greater than or
   equal to (≥)50%; Patients ≥16 years of age: Karnofsky ≥50%

   - Adequate end-organ function, as defined in the protocol

   - For females of childbearing potential: agreement to remain abstinent, use
   contraception, agreement to refrain from donating eggs. Females must remain abstinent
   or use two methods of contraception with a failure rate of <1% per year during the
   treatment and follow-up period (variable depending on the combination agent) or in
   accordance with national prescribing information guidance regarding abstinence,
   contraception

   - For males: agreement to remain abstinent or use a condom, and agreement to refrain
   from donating sperm, with a female partner of childbearing potential or pregnant
   female partner, males must remain abstinent or use a condom during the treatment
   period and for follow-up period (variable, depending on the combination agent) or in
   accordance with national prescribing information guidance regarding abstinence,
   contraception

Additional Inclusion Criteria for Participants with Solid Tumors (including Neuroblastoma)

   - At least one evaluable or measurable radiological site of disease as defined by
   standard criteria for the participant's tumor type, or measurable bone marrow disease
   by morphology

   - Adequate hematologic end-organ function, as defined in the protocol

   - Tumor tissue from relapsed disease

Additional Inclusion Criteria for Patients with Leukemia

   - Bone marrow with ≥5% lymphoblasts by morphologic assessment at screening

   - Available bone marrow aspirate or biopsy from screening

Exclusion Criteria:

   - Primary Central Nervous System (CNS) tumors

   - Symptomatic CNS metastases that result in a neurologically unstable clinical state or
   require increasing doses of corticosteroids or local CNS-directed therapy to control
   the CNS disease

   - CNS3 leukemia

   - Acute promyelocytic leukemia

   - White blood cell count >50 × 10^9 cells/Liter (L)

   - Down syndrome, Li-Fraumeni syndrome, history of severe aplastic anemia, or any known
   bone marrow failure predisposition syndrome

   - Burkitt-type acute lymphoblastic leukemia

   - T-cell lymphoblastic leukemia

   - Prior treatment with a MDM2 antagonist

   - Prior treatment with venetoclax (if potential for enrollment in a venetoclax arm)

   - Infection considered by the investigator to be clinically uncontrolled or of
   unacceptable risk to the participant

   - Any uncontrolled medical condition or other identified abnormality that precludes the
   patient's safe participation in and completion of the study

   - Systemic anticancer therapy within 28 days or 5 half-lives, whichever is shorter,
   prior to initiation of study treatment

   - Treatment with monoclonal antibodies, antibody drug conjugates, or cellular therapy
   for anti-neoplastic intent within 30 days prior to initiation of study treatment

   - I-131 meta-iodobenzylguanidine (MIBG) therapy within 6 weeks prior to initiation of
   study treatment

   - Myeloablative therapy with autologous or allogeneic hematopoietic stem cell rescue
   within 100 days of study treatment initiation

   - Immunosuppressive therapy for treatment of graft-versus-host disease within 2 weeks of
   study treatment initiation

   - Radiotherapy within 3 weeks prior to study treatment initiation

   - Specific restrictions are applicable for patients treated with drugs interacting with
   CYP2C8, CYP3A4, OATP1B1/B3, and P-gp

   - Received anti-coagulant or anti-platelet agent within 7 days or 5 half-lives prior to
   study treatment initiation

   - Underwent major surgical procedure within 21 days of study treatment initiation, or
   anticipate need for major surgical procedure during the course of the study