Optimal Timing of BR55 CEUS of the Ovaries

Inclusion Criteria: Enroll a subject in this study if the subject meets the following
inclusion criteria:

   - Is a female subject of at least 18 years of age;

   - Is premenopausal;

   - Is scheduled to undergo preventative salpingo-oophorectomy for high risk of ovarian
   cancer not earlier than 24 hours and not later than 5 days following the second BR55
   CEUS examination;

   - Provides written Informed Consent and is willing to comply with protocol requirements.

Exclusion Criteria: Exclude a subject from this study if the subject does not fulfill the
inclusion criteria, or if any of the following conditions are observed:

   - Is a pregnant or lactating female. Exclude the possibility of pregnancy:

      - by testing on site at the institution (serum βHCG) within 24 hours prior to the
      start of investigational product administration,

      - by surgical history (e.g., tubal ligation or hysterectomy),

   - Has undergone prior systemic therapy for ovarian cancer;

   - Has history of concurrent malignancy;

   - Has history of any clinically unstable cardiac condition including class III/IV
   congestive heart failure;

   - Has had any severe cardiac rhythm disorders within 7 days prior to enrolment;

   - Has severe pulmonary hypertension (pulmonary artery pressure >90mmHg) or uncontrolled
   systemic hypertension and/or respiratory distress syndrome;

   - Has open and/or non-healing wounds in the chest, abdomen and pelvis;

   - Has other systemic vascular abnormalities associated with neovascularization that in
   the opinion of the investigator could significantly affect the ability to evaluate the
   effects of BR55;

   - Is participating in a clinical trial or has participated in another trial with an
   investigational compound within the past 30 days prior to enrolment;

   - Has previously been enrolled in and completed this study;

   - Has any known allergy to one or more of the ingredients of the Investigational Product
   or to any other contrast media;

   - Is determined by the Investigator that the subject is clinically unsuitable for the
   study;

   - Has had major surgery, including laparoscopic surgery, within 3 months prior to
   enrolment;

   - Has history of surgery to the ovaries or pelvic inflammatory disease.