Trial Search Results
T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus
Type 1 diabetes is a condition that is caused in part by an abnormality of the immune system which occurs when T cells, which are part of the immune system, damage the insulin secreting cells (islet cells) in the pancreas. Although it is known that T cells are important mediators of the disease, progress in the development of reliable T cell assays has been modest. The purpose of this study is to learn which T cell assays are most reliable and reproducible so that the investigators can improve their understanding about how type 1 diabetes occurs.
Stanford is currently not accepting patients for this trial.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Procedure: T Cell Proliferation and Autoreactivity Assays
- Procedure: Cellular Immunoblot Assays
- Procedure: Tetramer Studies
- Procedure: Cytokine ELISPOT
To be eligible, individuals with type 1 diabetes must be:
- Diagnosed with type 1 diabetes within one year of first study visit
- 8-35 years of age at time of first visit
- Weigh > 40 kg (88 lbs) at time of first visit
- Individuals who will serve as control subjects who do not have type 1 diabetes cannot
have a first degree or second degree relative with type 1 diabetes.
Individuals must not:
- Have any major illness
- Be taking any steroid medications
- If female, should not be pregnant or breastfeeding.
Ages Eligible for Study
8 Years - 35 Years
Genders Eligible for Study