Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor

Inclusion Criteria:

   - Newly diagnosed Wilms' tumor meeting 1 of the following criteria:

      - Stage IV disease with favorable histology with or without loss of heterozygosity
      (LOH) for 1p and 16q

      - Stage III disease with favorable histology with LOH for 1p and 16q transferring
      from clinical trial COG-AREN0532

   - Patients must begin therapy within 14 days after surgery or biopsy, unless medically
   contraindicated

   - No bilateral Wilms' tumors (stage IV)

      - Patients should be referred to COG-AREN0534

   - Previously enrolled in clinical trial COG-AREN03B2

   - Karnofsky performance status (PS) 50-100% (for patients > 16 years of age) OR Lansky
   PS 50-100% (for patients ≤ 16 years of age)

   - Bilirubin ≤ 1.5 times upper limit of normal (ULN)

   - AST or ALT < 2.5 times ULN

   - Shortening fraction ≥ 27% by echocardiogram OR ejection fraction ≥ 50% by radionuclide
   angiogram

   - Not pregnant or nursing

   - Negative pregnancy test

   - Fertile patients must use effective contraception

   - No prior tumor-directed chemotherapy or radiotherapy unless transferring from clinical
   trial COG-AREN0532 OR treatment for emergent issues, as medically indicated

   - No concurrent aprepitant