Phase 2 Trial of Enzastaurin in Prostate Cancer in Participants Who Have Had Hormonal and Chemotherapy

Inclusion Criteria:

   - You are expected to be alive in the 12 weeks.

   - You are at least 18 years old.

   - You live close enough to the doctor's office to attend all of your required visits.

   - You have not been treated with chemotherapy for your prostate cancer (cohort 1).

   - Must have evidence of androgen-independent PSA-progressive disease without a history
   of or current (as judged by the investigator) clinical or radiographic evidence of
   metastatic disease with castrate levels of testosterone (<50 ng/dL) maintained by
   luteinizing hormone-releasing hormone (LHRH) agonist or bilateral orchiectomy
   following standard anti-androgen withdrawal. NOTE: PSA progression is defined as have
   rising PSA values of <=5 ng/mL (at least 3 measurements 1 week apart) with castrate
   levels of testosterone <50 ng/dL following appropriate antiandrogen withdrawal,
   without evidence of metastases. (cohort 1)

   - No prior systemic chemotherapy for prostate cancer. No prior chemotherapy for any
   other indication within 2 years of study entry. NOTE: Participants previously treated
   with chemotherapy in the adjuvant/neoadjuvant setting were not be eligible. (cohort 1)

   - You have had one prior docetaxel-based chemotherapy regimen (cohort 2).

   - You have evidence of metastatic prostate cancer with bone or soft tissue disease
   (cohort 2).

   - Must have evidence of docetaxel-resistant, androgen-independent metastatic prostate
   cancer with bone or soft tissue disease (PSA only participants are not eligible)
   defined as either: clinical, PSA or radiographic disease progression while receiving
   docetaxel-based therapy or PSA and/or radiographic progression at any time after
   completion of a docetaxel-containing regimen with PSA progression defined as a 25%
   increase in PSA from the post docetaxel value or interval progression in known
   metastatic sites of disease or development of new sites of disease on bone scan or
   computed tomography (CT) imaging. Note: Participants who discontinued a
   docetaxel-containing regimen due to toxicity or any other reasons not related to
   disease progression while on treatment, and were not able to complete at least 2
   cycles, were not be eligible. (cohort 2)

   - Your organs must be functioning properly.

Exclusion Criteria:

   - You are unable to swallow pills.

   - You have another illness besides your prostate cancer.

   - You have taken another experimental drug within the last 30 days.

   - You have a serious heart condition.

   - You are receiving another anti-cancer therapy.