An Open-label Study of Hydromorphone Oral Solution in Subjects Aged 28 Days to 16 Years for Postoperative Pain

Inclusion Criteria:

   - Pediatric subjects aged 28 days to 16 years,

   - Prospective subjects anticipated to have postoperative pain requiring oral opioid
   analgesics for at least 24 hours (up to 48 hours) following postoperative parenteral
   analgesia (up to 48 hours),

   - Prospective subjects have received no more than a total of 7 doses of opioids in the
   30 days prior to surgery.

Exclusion Criteria:

   - Prospective subjects with clinically significant hepatic or renal dysfunction and
   impaired cardiac and/or respiratory reserve,

   - Prospective subjects who have received opioid analgesic therapy other than
   hydromorphone or morphine sulfate during the up to 48-hour postoperative period prior
   to administration of first dose of oral hydromorphone,

   - Prospective subjects who have received regional anesthetic blockade OR analgesic
   treatment with nonopioid medication within 6 hours prior to administration of first
   dose of oral hydromorphone.

Other protocol-specific inclusion/exclusion criteria may apply.