Trial Search Results

Heritability of Opioid Effects: A Twin Study

Proposed twin study will test to what degree inter-individual differences in pain sensitivity and amount of pain relief in response to opioid therapy are inherited or alternatively, are due to environmental factors. This knowledge is important to guide future studies trying to explain such inter-individual differences. For example, finding that differences are largely due to environmental factors would discourage genomic studies and emphasize epidemiological studies.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Martin Angst

Collaborator: SRI International

Stanford Investigator(s):


  • Drug: Alfentanil
  • Other: Saline placebo infusion




Inclusion Criteria:Monozygotic or dizygotic twins ages 18-70

Exclusion Criteria:(1) Clinically relevant systemic diseases such as psychiatric,
neurological, and dermatological conditions interfering with the collection and
interpretation of study data (2) History of addiction (3) Allergy to study medication (4)
Chronic intake of medication potentially interfering with pain processing (except oral
contraceptives) (5) Intake of over-the-counter analgesics within the two days prior to
study (6) Reynaud's disease (7) Pregnancy (8) Participation in other study within last 30
days (9) Personnel with direct access to addicting drugs

Ages Eligible for Study

18 Years - 70 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Martha Tingle
Not Recruiting