Trial Search Results

Effects of an Herbal Topical Cream on Osteoarthritis Symptoms, Biomarkers, and Disease Progression in the Knee

Arthritis Relief Plus (ARP) Cream is a natural, herbal cream that has been shown to provide pain relief and decreased stiffness. Anecdotal reports suggest that pain may continue to be reduced months after cream use is stopped, indicating that there could be some disease-modifying effects of the cream. The purpose of this study is to test the claim that the ARP cream can provide long-term pain relief to osteoarthritis patients after only a short period of use. The study will also try to determine whether the pain relief is accompanied with any measurable indications that the progression of osteoarthritis has slowed or halted

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):


  • Drug: herbal topical cream


Early Phase 1


Inclusion Criteria:-Men and women between 40-70 years old

   - Have a history of knee pain

   - Exhibit mild osteoarthritis on the knee, as determined by Dr. Gold through MRIs and
   radiographs (if available). Exclusion Criteria:-Outside of age range

   - Prior knee surgery

   - History of knee or knee ligament instability

   - History of intermittent or persistent knee joint swelling

   - History of trauma to the knee or lower extremities resulting in fracture, tears of
   menisci, ligaments or joint capsule, or cartilage damage

   - Unable to have MRI scan due to the presence of metallic internal devices that would
   represent a risk factor for MRI and known or suspected pregnancy.

History of corticosteroid use

   - Kidney Disease

   - Knee diameter greater than 17cm and body diameter greater than 60 cm due to the
   physical constraints of the MRI

Ages Eligible for Study

40 Years - 70 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Jill Fattor, M.S.