Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults With Growth Hormone Deficiency

Inclusion Criteria:

   - Ability to provide written informed consent and comply with study assessments for the
   full duration of the study

   - Age 18-65 years old

   - Both men and women

   - Naive to GH replacement therapy

   - Diagnosis of Growth Hormone deficiency, adult onset

   - Good general health

   - Normal thyroid, adrenal or gonadal function, or stable thyroid, glucocorticoid (at
   replacement doses) and gonadal replacement therapy for at least 3 months prior to
   study initiation. If subjects are receiving transdermal testosterone, attainment of
   mid-normal serum values will be considered adequate. If subjects are on intramuscular
   testosterone, attainment of mid-normal serum testosterone at mid-injection cycle will
   be considered adequate

Exclusion Criteria:

   - Pregnancy (positive pregnancy test) prior to enrollment in the study

   - Any other condition that the investigator believes would pose a significant hazard to
   the subject if Growth Hormone therapy was initiated

   - Idiopathic Growth Hormone Deficiency

   - DSM IV diagnosis of Major Depressive Disorder with or without psychotic features,
   Bipolar II Disorder with or without psychotic features in a major depressive episode

   - Current use of psychotropic medications

   - History of moderate to severe brain injury

   - Clinically significant cardiovascular disease

   - Anemia with hct<30

   - Renal insufficiency with creatinine >2.0

   - Recent history of excessive alcohol use

   - Participation in another simultaneous medical investigation or trial

   - Active neoplasm

   - Prader Willi Syndrome

   - History of brain radiation

   - Chemotherapy, past or present use

   - History of head or eye injury involving persistent metal fragments, and implanted
   electrical device (such as a heart pacemaker)