Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma

Inclusion Criteria:

   - All patients must be diagnosed with neuroblastoma, and categorized as high-risk at the
   time of diagnosis

   - At pre-ASCT evaluation, patients must meet the International Neuroblastoma Response
   Criteria (INRC) for complete response (CR), very good partial response (VGPR), or
   partial response (PR) for primary site, soft tissue metastases and bone metastases;
   patients who meet those criteria must also meet the protocol specified criteria for
   bone marrow response as outlined below: =< 10% tumor (of total nucleated cellular
   content) seen on any specimen from a bilateral bone marrow aspirate/biopsy; patients
   who have no tumor seen on the prior bone marrow, and then have =< 10% tumor on any of
   the bilateral marrow aspirate/biopsy specimens done at pre-ASCT and/or pre-enrollment
   evaluation will also be eligible; (Note that, per INRC, this would have been defined
   as an "overall" response of progressive disease [PD])

   - Prior to enrollment on ANBL0931, a determination of residual disease must be performed
   (tumor imaging studies including metaiodobenzylguanidine [MIBG] scan, computed
   tomography [CT] or magnetic resonance imaging [MRI], bone marrow aspiration and
   biopsy); this disease assessment is required for eligibility, and should be done
   preferably within 2 weeks but must be done within a maximum of 4 weeks before
   enrollment

      - Patients with residual disease are eligible; biopsy is not required

      - Patients must not have progressive disease except for protocol specified bone
      marrow response

   - All patients must have completed therapy including intensive induction chemotherapy
   followed by ASCT and radiotherapy to be eligible; radiotherapy may be waived for
   patients who either had a small adrenal mass which was completely resected upfront, or
   who never had an identifiable primary tumor

   - No more than 9 months from the date of starting the first induction chemotherapy after
   diagnosis to the date of ASCT except for the rare occasions as noted below; for tandem
   ASCT patients, this will be the date of the FIRST stem cell infusion; Exception: for
   those who are initially diagnosed as non-high risk neuroblastoma, but later converted
   (and/ or relapsed) to high risk neuroblastoma, the 9 months restriction should start
   from the date of induction therapy for high risk neuroblastoma (not from the initial
   induction therapy for non-high risk disease), to the date of ASCT

   - Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of
   age; required patients must have a Lansky or Karnofsky performance scale score of >=
   50%

   - Patients must have a life expectancy of >= 2 months (8 weeks)

   - Total absolute phagocyte count (APC = neutrophils + monocytes) is at least 1000/uL

   - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
   mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:

      - 1 month to < 6 months: 0.4 mg/dL

      - 6 months to < 1 year: 0.5 mg/dL

      - 1 to < 2 years: 0.6 mg/dL

      - 2 to < 6 years: 0.8 mg/dL

      - 6 to < 10 years: 1 mg/dL

      - 10 to < 13 years: 1.2 mg/dL

      - 13 to < 16 years: 1.5 mg/dL (male), 1.4 mg/dL (female)

      - >= 16 years: 1.7 mg/dL (male), 1.4 mg/dL (female)

   - Total bilirubin =< 1.5 x upper limit of normal (ULN) for age

   - Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 5 x
   upper limit of normal (ULN) for age

   - SOS (sinusoidal obstruction syndrome, formerly known as veno-occlusive disease [VOD]),
   if present, should be stable or improving

   - Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 55% by
   radionuclide angiography

   - No evidence of dyspnea at rest

   - If pulmonary function tests (PFTs) are performed, forced expiratory volume in one
   second (FEV1)/forced vital capacity (FVC) > 60% by pulmonary function test

   - Patients with seizure disorder may be enrolled if on anticonvulsants and well
   controlled

   - Central nervous system (CNS) toxicity < grade 2

Exclusion Criteria:

   - Females of childbearing potential must have a negative pregnancy test

   - Patients of childbearing potential must agree to use an effective birth control method

   - Female patients who are lactating must agree to stop breast-feeding

   - Patients must not have received prior anti-GD2 antibody therapy

   - Patients must not have received prior vaccine therapy administered as treatment of
   neuroblastoma not routine infectious disease vaccinations