Trial Search Results

Study of Experimental Models of Pain and Inflammation.

The experimental pain model studied in this proposal show characteristics of an inflamed wound with a pro-inflammatory response. This study will help discover candidate genetic and/or proteomic pain biomarkers that could provide objective and mechanism based tests to diagnose, monitor or quantify pain. We also hope to determine the measurable effects of a known non-steroidal anti-inflammatory drug (NSAID) on biomarkers of pain and inflammation.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Martin Angst

Stanford Investigator(s):


  • Drug: Ibuprofen
  • Drug: Placebo tablet


Phase 1


Inclusion Criteria:1) Age 18-60 2) Skin type II or III according to classification of
Fitzpatrick 3) Negative pregnancy test (women of childbearing potential) 4) Willing and
able to sign an informed consent form and Health Insurance Portability and Accountability
Act (HIPAA) authorization and to comply with study procedures

Exclusion Criteria:1) History of acute or chronic illness that may hinder study procedures
or confuse interpretation of the data (e.g. dermatological, neurological, psychiatric or
addictive diseases) 2) Clinically significant cardiovascular, pulmonary, hepatic or renal
diseases 3) Major bodily injury within 3 months of study participation 4) Surgery within 3
months of study participation 5) Pregnancy or breast-feeding 6) Intake of prescription
drugs with anti/pro-inflammatory action 7) Intake of prescription drugs with
anti/pro-analgesic action 8) Inability to abstain from any anti/pro inflammatory drugs
during the 24-hour period preceding a study session 9) Inability to abstain from any
anti/pro-analgesic drugs during the 24-hour period preceding a study session 10) Prior
medical history that would contraindicate the use of NSAID, or previous negative reaction
to NSAIDs or aspirin 11) Inability to obtain at least 6 hours of sleep during the night
preceding a study session

Ages Eligible for Study

18 Years - 60 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Martin Angst
Not Recruiting