Inclusion Criteria:

Case participants:

   - All participants must be 18 years of age or older

   - SZ patients must meet lifetime (DSM-IV) criteria for schizophrenia, any subtype

   - BP patients must have a confirmed bipolar type I diagnosis, which requires a history
   of a mixed or manic episode at some prior point, regardless of subsequent affective
   episodes

   - all patients must have medical records available in the VA CPRS

   - all patients must be competent to provide informed consent for the research

Control participants:

   - Enrollment in the VA Million Veteran Program

Exclusion Criteria:

Case participants:

   - SZ and BP patients that have participated in a previous GWAS study or are currently
   participating in a clinical treatment study

   - patients with physical, sensory, or intellectual limitations that preclude their
   assessment with performance-based measures

   - patients with active illicit drug use that might hamper assessments. Potential
   participants who present under the apparent influence of alcohol or drugs will be
   rescheduled once and excluded if they are intoxicated at their next appointment;
   patients identified via electronic medical record review will be screened for evidence
   of active drug abuse and excluded

Control participants:

   - a personal history identifiable in the VA EMR of a major psychiatric disorder related
   to psychosis or a first degree family member with either schizophrenia or bipolar
   disorder

   - major neurologic illnesses, or systemic medical illnesses, that could interfere with
   central nervous system function

   - current treatment with psychotropic medications aimed at psychosis, bipolar disorder,
   or major depression

   - anyone participating in an ongoing randomized trial of therapy for SZ or BP