Trial Search Results

CSP #572 - Genetics of Functional Disability in Schizophrenia and Bipolar Illness

The purpose of this study is to detect genetic associations for the development of schizophrenia (SZ) and bipolar illness (BP) by comparing Veterans with these diseases to "psychiatrically healthy" Veterans from Veterans Health Administration medical centers. In addition, the genetic basis for functional capacity and disability in Veterans affected with SZ and BP will be assessed, as will genetic predictors of suicidality and tardive dyskinesia. Finally, we will also establish a repository which allows for future genomic studies related to SZ, BP, and related disorders or sequelae.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

US Department of Veterans Affairs

Stanford Investigator(s):

Eligibility


Inclusion Criteria:

Case participants:

   - All participants must be 18 years of age or older

   - SZ patients must meet lifetime (DSM-IV) criteria for schizophrenia, any subtype

   - BP patients must have a confirmed bipolar type I diagnosis, which requires a history
   of a mixed or manic episode at some prior point, regardless of subsequent affective
   episodes

   - all patients must have medical records available in the VA CPRS

   - all patients must be competent to provide informed consent for the research

Control participants:

   - Enrollment in the VA Million Veteran Program

Exclusion Criteria:

Case participants:

   - SZ and BP patients that have participated in a previous GWAS study or are currently
   participating in a clinical treatment study

   - patients with physical, sensory, or intellectual limitations that preclude their
   assessment with performance-based measures

   - patients with active illicit drug use that might hamper assessments. Potential
   participants who present under the apparent influence of alcohol or drugs will be
   rescheduled once and excluded if they are intoxicated at their next appointment;
   patients identified via electronic medical record review will be screened for evidence
   of active drug abuse and excluded

Control participants:

   - a personal history identifiable in the VA EMR of a major psychiatric disorder related
   to psychosis or a first degree family member with either schizophrenia or bipolar
   disorder

   - major neurologic illnesses, or systemic medical illnesses, that could interfere with
   central nervous system function

   - current treatment with psychotropic medications aimed at psychosis, bipolar disorder,
   or major depression

   - anyone participating in an ongoing randomized trial of therapy for SZ or BP

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Lauren Drag, PhD
650-493-5000 Ext. 61237
Not Recruiting