Trial Search Results

Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH

FSGS is an immunologic disorder wherein circulating immune proteins cause damage to the kidneys and progressive injury and scarring. Corticosteroid therapy is occasionally, but not nearly universally, successful in reducing proteinuria, and when patients respond, they have a favorable prognosis. The investigators believe that ACTH therapy (H.P. Acthar Gel) can provide a more rapid, well tolerated reduction in glomerular injury.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Mallinckrodt

Stanford Investigator(s):


  • Drug: H.P. Acthar Gel


Phase 4


Inclusion Criteria:

   - 1. Biopsy proven FSGS

   - 2. Ability to consent and complete study evaluations

   - 3. Greater than 2g/day of proteinuria

   - 4. No contraindications to treatment with corticosteroids or ACTH

   - 5. Women of childbearing potential will agree to use effective forms of birth control
   throughout this study

Exclusion Criteria:

   - 1. Known secondary cause of FSGS

   - 2. Receiving active immune therapy (within 90 days)

   - 3. Pregnancy

   - 4. Creatinine >2.5 mg/dl

   - 5. Uncontrolled HTN (>180/100mm Hg)

   - 6. Diabetes

   - 7. Acute or chronic infection

   - 8. Severe comorbidity (active coronary, cerebrovascular disease, cancer, psychiatric

   - 9. Age < 16, >65 years

   - 10. Evidence of untreated tuberculosis (+PPD or Ellispot Gold testing)

   - 11. A known contraindication to ACTH. Corticotropin is considered contraindicated in
   patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes
   simplex, recent surgery, history of or the presence of a peptic ulcer, congestive
   heart failure, uncontrolled hypertension, or sensitivity to proteins of porcine

Ages Eligible for Study

16 Years - 65 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Richard Lafayette
(650) 723-6248