Phase I Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate Cancer

Inclusion Criteria:

   1. Histologically confirmed adenocarcinoma of the prostate

   2. Castration-resistant prostate cancer requires the following 3 criteria:

      - Failure of first line bilateral orchiectomy or therapy with an LHRH agonist,

      - A rising PSA on 3 consecutive occasions at least 1 week apart (but not limited to
      the 30 day screening period), AND

      - A castrate level of testosterone (<50ng/dL)

   3. PSA doubling time (PSADT) > 1 months

   4. Failure on docetaxel chemotherapy as defined by a rising PSA .

   5. A minimum PSA of 2 ng/mL

   6. Age >=18 years

   7. Life expectancy greater than 6 months

   8. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 or Karnofsky
   performance status >=80%

   9. Bone metastases will be allowed

10. The subject has a QTcB (Bazett corrected) or QTcF (Frederica corrected) < 470 msec.

11. Ability to understand and the willingness to sign a written informed consent document.

12. Willingness to stay on docetaxel chemotherapy despite rising PSA level.

Exclusion Criteria:1. Radiotherapy for prostate cancer within 28 days prior to Day 1.

2. More than 1 prior chemotherapy

3. Inadequate organ function, as evidenced by any of the following at screening:

   - Absolute neutrophil count (ANC) < 1500/uL

   - Platelet count <= 100 x 10^9/L

   - Total bilirubin >= ULN

   - AST, and/or ALT > 1.5 x the upper limit of normal (ULN) with a concomitant alkaline
   phosphastase >2.5 X ULN

   - Serum creatinine > 2.0 mg/dL

   - Hemoglobin < 9 g/dL

   4. Men with reproductive potential who do not agree to use an accepted and effective
   method of contraception during the study treatment period and for at least 3 months
   after completion of the study treatment.

   5. History of other malignancies within 5 years prior to Day 1 except for tumors with
   a negligible risk for metastasis or death, such as adequately controlled basal cell
   carcinoma, squamous-cell carcinoma of the skin, or early-stage bladder cancer

   6. Current, recent (within 4 weeks of the first infusion of this study), or planned
   participation in an experimental drug study.

   7. Known or prior treated brain metastases.

   8. History of hypersensitivity to docetaxel

   9. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
   infection, symptomatic congestive heart failure ,unstable angina pectoris, cardiac
   arrhythmia, significant vascular disease (e.g. aortic aneurysm, aortic dissection),
   symptomatic peripheral vascular disease, or psychiatric illness/social situations that
   would limit compliance with study requirements.

   10. History of myocardial infarction or unstable angina within 6 months prior to study
   enrollment

   11. History of stroke or transient ischemic attack within 6 months prior to study
   enrollment 12. The subject is known to be positive for the human immunodeficiency
   virus (HIV) and is receiving antiretroviral 12. Willingness to stay on docetaxel
   chemotherapy despite rising PSA level.