A Study to Evaluate a Multiple Model Probabilistic Predictive Controller (MMPPC) for Closed Loop Insulin Delivery

Inclusion Criteria:

Eligibility

To be eligible for the study, all subjects must meet the following criteria:

   1. Clinical diagnosis of type 1 diabetes and using daily insulin therapy for at least one
   year. The diagnosis of type 1 diabetes is based on the investigator's judgment;
   Cpeptide level and antibody determinations are not needed.

   2. Age 21 years to less than 45.0 years

   3. Subject has used a downloadable insulin pump for at least 3 months

   4. Subject understands the study protocol and agrees to comply with it

   5. Informed Consent Form signed

   6. A Personal Home computer with internet access (must have access to a PC for uploading,
   not a Mac).

Exclusion Criteria:

Exclusion

Subjects who meet any of the following criteria are not eligible for the study:

   1. The presence of a significant medical disorder that in the judgment of the
   investigator will affect the wearing of the sensors or the completion of any aspect of
   the protocol.

   2. The presence of any of the following diseases:

      - Asthma if treated with systemic or inhaled corticosteroids in the last 6 months

      - Cystic fibrosis

      - Other major illness that in the judgment of the investigator might interfere with
      the completion of the protocol Adequately treated thyroid disease and celiac
      disease do not exclude subjects from enrollment

   3. Inpatient psychiatric treatment in the past 6 months

   4. Current use of oral/inhaled glucocorticoids or other medications, which in the
   judgment of the investigator would be a contraindication to participation in the
   study.

   5. Pregnancy, breast feeding, or intention of becoming pregnant in the next 2 months.

   6. Weight less than 26 kg

   7. Renal failure or peritoneal dialysis

   8. History of heart disease

   9. The use of beta-blockers

10. History of cerebrovascular disease, or non-hypoglycemic seizures, or intolerance of
   glucagon treatment.

11. History of a hypoglycemic seizure within 6 months of enrollment.