Trial Search Results
Triclosan, Triclocarban, and the Microbiota
Triclosan (5-chloro-2 (22,4-dichlorophenoxy)phenol) is a broad-spectrum antibacterial and antifungal agent that is found in thousands of common household products, including deodorants, toothpaste, "antibacterial" soaps, cleaning products, kitchen utensils, bedding, socks, trash bags. The benefits of triclosan have not been proven except in reducing plaque and gingivitis when used in toothpaste. In this study, the investigators intend to look at whether exposure to triclosan changes the colonizing flora of the skin, gut and mouth as well as changes in certain blood hormone levels, including adipocytokines, androgens, and inflammatory markers. Changes in the gut microbiota have been associated with a variety of disease states such as inflammatory bowel disease, colorectal cancer. Additionally, reductions in the microbiome diversity have been associated with obesity.
Stanford is currently not accepting patients for this trial.
- Other: triclosan/triclocarban-containing personal care products
- Health subjects
- Age >18 years
- Recent travel to the developing world (within 3 months)
- Recent use of antibiotics (within 3 months)
- Unwillingness to change personal care/hygiene products
- Recent gastrointestinal illness (within 3 months)
- Individuals who are unlikely to be available for the 10 months of the study period.
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study