Trial Search Results

Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD

The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD).

The purpose of which is to evaluate changes in both PTSD symptoms and alcohol use and cravings associated with Cognitive Processing Therapy (CPT) or Relapse Prevention (RP) treatment in individuals with PTSD/AUD, along with mediators and moderators of outcomes.

The study will randomize 235 PTSD/AUD participants recruited from the VA and from the community to CPT, RP, or Interactive Voice Response (IVR) assessment only (AO). Those in the AO condition will be re-randomized after the treatment phase to either RP or CPT. Individuals will be assessed pretreatment, immediately post-treatment, 3-, 6-, 9-, and 12-months post-treatment and will monitor symptoms daily throughout treatment.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

University of Washington

Collaborator: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Stanford Investigator(s):


  • Behavioral: Cognitive Processing Therapy (CPT)
  • Behavioral: Relapse Prevention (RP)




Inclusion Criteria:

   - Men and women age ≥ 18 years with a current DSM-V diagnosis of alcohol

   - Recent alcohol consumption for at least 2 weeks in the past 30 day period OR at least
   2 days of heavy drinking in the past 30 day period

   - Desire to abstain from alcohol

   - Current DSM-V (Diagnostic and Statistical Manual of Mental Disorders) diagnosis of

   - Capacity to provide informed consent

   - English fluency

Exclusion Criteria:

   - Men and women with an unstable psychiatric medication regimen

   - Current trauma-focused mental health treatment (MH) or behaviorally focused alcohol
   dependence (AD) AD/MH treatment in the past 30 days

   - Suicide attempt or suicidal ideation with intent or plan, or self-harm in the past

   - Presence of a psychotic disorder or uncontrolled Bipolar Disorder

   - Signs or symptoms of alcohol withdrawal at the time of initial consent

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting