An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy Who Previously Participated in ISIS 396443-CS1 (NCT01494701)

Key Inclusion Criteria:

   - Clinical signs attributable to Spinal Muscular Atrophy

   - Satisfactory completion of dosing and all study visits in ISIS 396443-CS1
   (NCT01494701) with an acceptable safety profile, per Investigator judgement.

   - Able to complete all study procedures, measurements and visits and parent/participant
   has adequately supportive psychosocial circumstances, in the opinion of the
   investigator

   - Estimated life expectancy > 2 years from Screening

   - Meets age-appropriate institutional criteria for use of anesthesia/sedation, if use is
   planned for study procedure

Key Exclusion Criteria:

   - Have any new or worsening of existing condition which in the opinion of the
   Investigator would make the participant unsuitable for enrollment, or could interfere
   with the participant participating in or completing the study.

   - Dosing in ISIS 396443-CS1 (NCT01494701) within 270 days (9 months) of screening, or
   longer ago than 450 days (15 months)

   - Dosing in ISIS 396443-CS2 (NCT01703988)

   - Hospitalization for surgery (i.e. scoliosis surgery) or pulmonary event within 2
   months of screening or planned during the duration of the study

   - Presence of an untreated or inadequately treated active infection requiring systemic
   antiviral or antimicrobial therapy any time during the screening period

   - Clinically significant abnormalities in hematology or clinical chemistry parameters

   - Treatment with investigational drug, biological agent, or device within 1-month of
   Screening or 5 half-lives of study agent, whichever is longer. Treatment with
   valproate or hydroxyurea within 1 months of screening. Any history of gene therapy or
   cell transplantation

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.