My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors

General Inclusion Criteria:

   - Life expectancy greater than or equal to (≥) 12 weeks

   - Histologically documented metastatic cancer (solid tumors, not including hematologic
   malignancies)

   - Participants who have received standard first-line therapy for metastatic cancer
   (except for the tumors for which no first-line therapy exists) and in whom a trial of
   targeted therapy is considered the best available treatment option. Eligible
   participants should not have available therapies that will convey clinical benefit
   and/or are not suitable options per the treating physician's judgment

   - No previous treatment with the specific assigned study drug or any other drug sharing
   the same target

   - Measurable disease by RECIST v1.1

   - Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of 0 or 1 (For
   patients enrolling in the atezolizumab arm, ECOG score must be documented within 7
   days prior to first treatment and confirmation of ECOG PS must be entered into the
   interactive web response system [IWRS] prior to initiation of treatment)

   - Adequate hematologic, renal, and liver function as defined by the protocol

   - If applicable, use of contraception methods or abstinence as defined by the protocol

Study-Drug Specific Inclusion Criteria:

Trastuzumab plus Pertuzumab

   - Molecular testing results from clinical laboratory improvement amendments
   (CLIA)-certified laboratories (using tissue and/or blood) demonstrating HER2
   overexpression or amplification. Participants must have one of the following tumor
   types: biliary cancer, salivary cancer, or bladder cancer

   a) For participants screened using a blood assay: obtain tissue-based testing result
   confirming study eligibility (within first 4 weeks after enrollment)

   - Left ventricular ejection fraction (LVEF) greater than (>) 50 percent (%) or above the
   lower limit of the institutional normal range, whichever is lower

   - Availability of an archival or new pre-treatment tissue sample is required if
   molecular testing was not performed by Foundation Medicine. Any available tumor tissue
   sample can be submitted. The tissue sample must be submitted within 4 weeks after
   enrollment

Erlotinib

   - Molecular testing results from CLIA-certified laboratories (using tissue and/or blood)
   demonstrating epidermal growth factor receptor (EGFR)-activating mutations

Vemurafenib plus Cobimetinib

   - Molecular testing results from CLIA-certified laboratories (using tissue and/or blood)
   demonstrating BRAF V600 mutations a) For participants screened using a blood assay:
   obtain tissue-based testing result confirming study eligibility (within first 4 weeks
   after enrollment)

Vismodegib

   - Molecular testing results from CLIA-certified laboratories (using tissue and/or blood)
   demonstrating hedgehog pathway relevant mutation (activating mutation of smoothened
   [SMO] or loss-of-function mutation of protein patched homolog-1 [PTCH-1])

   a) For participants screened using a blood assay: obtain tissue-based testing result
   confirming study eligibility (within first 4 weeks after enrollment)

   - All non-hematological adverse events related to any prior chemotherapy, surgery, or
   radiotherapy must have resolved to National Cancer Institute Common Terminology
   Criteria for Adverse Events (NCI CTCAE) Grade less than or equal to (≤) 2 prior to
   starting therapy

Alectinib

   - Molecular testing results from CLIA-certified laboratories (using tissue and/or blood)
   demonstrating anaplastic lymphoma kinase (ALK) gene rearrangements, ALK mutations, ALK
   copy number gain or (for melanoma only) increased ALK expression or presence of
   ALK-alternative transcription initiation transcript (ALKATI) a) For participants
   screened using a blood assay: obtain tissue-based testing result confirming study
   eligibility (within first 4 weeks after enrollment)

Atezolizumab

   - Molecular testing results from CLIA-certified laboratories (using tissue)
   demonstrating elevated tissue tumor mutational burden (tTMB ≥10 mutations/ Megabase
   [Mb])

   - For patients where molecular testing was not performed using Foundation Medicine,
   submission of an archival or new pretreatment tissue sample is mandatory. For patients
   where molecular testing was performed using Foundation Medicine, submission of an
   archival or new pretreatment tissue sample is required, if available. The tissue
   sample must be submitted within 4 weeks after enrollment

General Exclusion Criteria:

   - Participants with hematologic malignancies

   - Concurrent administration of any other anti-cancer therapy (except male participants
   with prostate cancer receiving androgen blockade): Bisphosphonates and denosumab are
   allowed; Most recent anti-cancer therapy ≤28 days and have not recovered from the side
   effects, excluding alopecia; Radiation therapy within ≤14 days

   - Active or untreated brain metastases

   - History of carcinomatous meningitis

   - Uncontrolled concurrent malignancy (early stage is allowed if not requiring active
   therapy or intervention)

   - Pregnant or breastfeeding women, or intending to become pregnant during the study

   - Any significant cardiovascular events within 6 months prior to study entry

   - Pulmonary embolism within 30 days prior to study entry

   - History or presence of clinically significant ventricular or atrial dysrhythmia >Grade
   2 per NCI CTCAE v4.0

   - Any other severe acute or chronic medical or psychiatric condition or laboratory
   abnormality that may increase the risk associated with study participation or may
   interfere with the interpretation of study results

   - Psychological, familial, sociological, or geographical conditions that do not permit
   compliance with the protocol

Study-Drug Specific Exclusion Criteria:

Trastuzumab plus Pertuzumab

   - Previous treatment with any HER2-targeted therapy

Erlotinib

   - Non-small cell lung cancer (NSCLC) or pancreatic cancer identified by exon 19
   deletions or exon 21 L858R substitution mutations

   - EGFR amplifications in the absence of EGFR-activating mutations

   - Cancers with exon 20 mutations

   - Previous treatment with erlotinib or any other EGFR inhibitor

   - Inability to swallow pills

   - Refractory nausea and vomiting, malabsorption, external biliary shunt, or significant
   bowel resection that would preclude absorption of erlotinib

Vemurafenib plus Cobimetinib

   - Malignant melanoma, papillary thyroid cancer, colorectal cancer, or hematologic
   malignancy including multiple myeloma

   - LVEF below institutional lower level of normal (LLN) or below 50%, whichever is lower

   - History of or evidence of retinal pathology on ophthalmologic examination that is
   considered a risk factor for neurosensory retinal detachment, retinal vein occlusion
   (RVO), or neovascular macular degeneration

   - Presence of any of the following conditions, which are risk factors for RVO:
   Uncontrolled glaucoma with intraocular pressure >21 millimetres of mercury (mm Hg);
   Serum cholesterol ≥Grade 2; Hypertriglyceridemia ≥Grade 2; Hyperglycemia (fasting)
   ≥Grade 2; Grade ≥2 uncontrolled hypertension (participants with a history of
   hypertension controlled with anti-hypertensive medication to Grade
   - Prior or concurrent malignancy with known RAS mutation

   - Previous treatment with vemurafenib or any other BRAF inhibitor (prior sorafenib is
   allowed)

   - Previous treatment with cobimetinib or any other mitogen-activated
   protein/extracellular signal-regulated kinase (MEK) inhibitor

   - Prior treatment with a RAF inhibitor

   - Inability to swallow pills

   - Refractory nausea and vomiting, malabsorption, external biliary shunt, or significant
   bowel resection that would preclude absorption of vemurafenib

   - History of congenital long QT syndrome or mean (average of triplicate measurements)
   corrected QT (QTc) measured using Fridericia's method ≥450 millisecond (ms) at
   baseline or uncorrectable abnormalities in serum electrolytes (sodium, potassium,
   calcium, magnesium, phosphorus)

Vismodegib

   - Basal cell carcinoma of the skin, medulloblastoma, small-cell lung cancer, or
   hematologic malignancies

   - Previous treatment with vismodegib or any other hedgehog pathway inhibitor

   - Inability to swallow pills

   - Refractory nausea and vomiting, malabsorption, external biliary shunt, or significant
   bowel resection that would preclude absorption of vismodegib

Alectinib

   - ALK-positive NSCLC, neuroblastoma, and childhood tumors

   - Previous treatment with alectinib or any other ALK inhibitor

   - Participants with symptomatic bradycardia

   - Administration of strong/potent cytochrome P3A4 (CYP3A4) inhibitors or inducers within
   14 days prior to the first dose of study treatment and while on treatment with
   alectinib

   - Inability to swallow pills

   - Refractory nausea and vomiting, malabsorption, external biliary shunt, or significant
   bowel resection that would preclude absorption of alectinib

Atezolizumab

   - History of leptomeningeal disease

   - Uncontrolled tumor pain

   - Asymptomatic metastatic lesions that would likely cause functional deficits or
   intractable pain with further growth (e.g., epidural metastasis that is not currently
   associated with spinal cord compression) should be considered for loco-regional
   therapy if appropriate prior to enrollment

   - Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent
   drainage procedures (once monthly or more frequently). Patients with indwelling
   catheters are allowed

   - Uncontrolled or symptomatic hypercalcemia

   - Previous treatment with atezolizumab or another programmed death-1 (PD-1)/PD-L1
   inhibitor

   - History of severe allergic, anaphylactic, or other hypersensitivity reactions to
   chimeric or humanized antibodies or fusion proteins

   - Known hypersensitivity to biopharmaceutical agents produced in Chinese hamster ovary
   cells

   - Known allergy or hypersensitivity to any component of the atezolizumab formulation

   - Active or history of autoimmune disease or immune deficiency

   - Prior allogeneic stem cell or solid organ transplantation

   - History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis
   obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of
   active pneumonitis on screening chest computed tomography (CT) scan

   - Positive human immunodeficiency virus (HIV) test, active hepatitis B virus (HBV)
   infection, active hepatitis C virus (HCV) infection or active tuberculosis

   - Severe infection within 4 weeks prior to initiation of study treatment

   - Treatment with therapeutic oral or IV antibiotics within 2 weeks prior to initiation
   of study treatment

   - Significant cardiovascular disease, such as New York Heart Association cardiac disease
   (Class II or greater), myocardial infarction, or cerebrovascular accident within 3
   months prior to initiation of study treatment, unstable arrhythmia, or unstable angina

   - Major surgical procedure other than for diagnosis within 4 weeks prior to initiation
   of study treatment, or anticipation of need for a major surgical procedure during the
   course of the study

   - Treatment with a live, attenuated vaccine within 4 weeks prior to initiation of study
   treatment, or anticipation of need for such a vaccine during the course of the study
   or within 5 months after the final dose of atezolizumab

   - History of other malignancy within 5 years prior to screening, with the exception of
   those with a negligible risk of metastasis or death, such as adequately treated
   carcinoma in situ of the cervix, non-melanoma skin carcinoma, localized prostate
   cancer, ductal carcinoma in situ, or Stage I uterine cancer

   - Any other disease, metabolic dysfunction, physical examination finding, or clinical
   laboratory finding that contraindicates the use of an investigational drug, may affect
   the interpretation of the results, or may render the participant at high risk from
   treatment complications

   - Prior treatment with cluster of differentiation 137 (CD137) agonists or immune
   checkpoint blockade therapies

   - Treatment with systemic immunostimulatory agents within 4 weeks or five half-lives of
   the drug (whichever is longer) prior to randomization

   - Treatment with systemic immunosuppressive medication within 2 weeks prior to
   initiation of study treatment, or anticipation of need for systemic immunosuppressive
   medication during the course of the study