Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma

Inclusion Criteria:

   - T-ALL: T-ALL patients must be enrolled on AALL08B1 or Project:EveryChild (APEC14B1, if
   open for the classification of ALL patients) prior to treatment and enrollment on
   AALL1231

   - All patients must be > 1 and < 31 years of age

   - Patients must have newly diagnosed T-lymphoblastic leukemia (T-ALL) or T-lymphoblastic
   lymphoma (T-LLy) stages II-IV

      - Note: a diagnosis of T-ALL is established when leukemic blasts lack
      myeloperoxidase or evidence of B-lineage derivation (cluster of differentiation
      [CD]19/CD22/CD20), and express either surface or cytoplasmic CD3 or two or more
      of the antigens CD8, CD7, CD5, CD4, CD2 or CD1a, and are present either in
      peripheral blood or > 25% in the bone marrow; if surface CD3 is expressed on all
      leukemic cells, additional markers of immaturity, including terminal
      deoxynucleotidyl transferase (TdT), CD34 or CD99 will be assessed for expression;
      cases with uncertain expression will receive additional review within the
      appropriate Children's Oncology Group (COG) reference laboratory

      - For T-LLy patients with tissue available for flow cytometry, the criterion for
      diagnosis should be analogous to T-ALL; for tissue processed by other means (i.e.
      paraffin blocks), the methodology and criteria for immunophenotypic analysis to
      establish the diagnosis of T-LLy defined by the submitting institution will be
      accepted

   - All patients and/or their parents or legal guardians must sign a written informed
   consent; assent, when appropriate, will be obtained according to institutional
   guidelines

Exclusion Criteria:

   - Patients must not have received any cytotoxic chemotherapy for either the current
   diagnosis of T-ALL, T-L-Ly or for any cancer diagnosis prior to the initiation of
   protocol therapy on AALL1231, with the exception of:

      - Steroid pretreatment: prednisone or methylprednisolone for =< 120 hours (5 days)
      in the 7 days prior to initiating induction chemotherapy or for =< 336 hours (14
      days) in the 28 days prior to initiating induction chemotherapy; prior exposure
      to ANY steroids that occurred > 28 days before the initiation of protocol therapy
      does not affect eligibility; the dose of prednisone or methylprednisolone does
      not affect eligibility

      - Intrathecal cytarabine (the CNS status must be determined based on a sample
      obtained prior to administration of any systemic or intrathecal chemotherapy,
      except for steroid pretreatment) system chemotherapy must begin with 72 hours of
      this IT therapy; or

      - Pretreatment with hydroxyurea; or

      - 600 cGy of chest irradiation, if medically necessary

         - Pre-treatment with dexamethasone in the 28 days prior to initiation of
         protocol therapy is not allowed with the exception of a single dose of
         dexamethasone use during sedation to prevent or treat airway edema;
         inhalation steroids and topical steroids are not considered pretreatment

   - Pre-existing >= grade 2 sensory or motor peripheral neurotoxicity

   - Uncontrolled seizure disorder

   - Diagnosis of Down syndrome (Trisomy 21)

   - Patients who are pregnant since fetal toxicities and teratogenic effects have been
   noted for several of the study drugs; a pregnancy test is required for female patients
   of childbearing potential

   - Lactating females who plan to breastfeed

   - Sexually active patients of reproductive potential who have not agreed to use an
   effective contraceptive method for the duration of their study participation

   - Patient has hypersensitivity to bortezomib, boron, or mannitol

   - Serious medical or psychiatric illness likely to interfere with participation in this
   clinical study

   - Participation in clinical trials with other investigational agents not included in
   this trial, within 14 days of the start of this trial and within 30 days of any dose
   of bortezomib