Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies

Key Inclusion Criteria:

   1. Have documented CD20+ B-cell malignancy, with active disease not responsive to prior
   therapy, for whom no standard of care options exists, and for whom treatment with an
   anti-CD20 antibody may be appropriate:

      - Part A (IV administration) B-NHL confirmed by National Cancer Institute (NCI)
      working group criteria

      - Part B (SC administration): Confirmed diagnosis of B-NHL requiring therapy as
      defined by WHO classification 2017

   2. Patients with B-NHL must have had prior treatment with an anti-CD20 antibody therapy.
   Patients with CLL (Part A only) are not required to have received prior treatment with
   an anti-CD20 antibody therapy as defined in the protocol.

      - For the inclusion in the disease-specific expansion cohort enrolling DLBCL
      patients after failure of CAR-T therapy, the patient must have recovered from the
      toxicities of the lymphodepletion therapy and CAR-T infusion.

      - For inclusion in Part B, patients must have FL grade 1-3a or DLBCL (with or
      without prior CAR-T) per the criteria above, and:

      - Patients with FL grade 1-3a and DLBCL must have received at least 2 prior lines
      of systemic therapy, including an anti-CD20 antibody and an alkylating agent

   3. All patients must have at least one bi-dimensionally measurable lesion ≥1.5 cm)
   documented by CT or MRI scan, if CT scan is not feasible.

   4. Eastern Cooperative Oncology Group (ECOG) performance status ≤1

   5. Life expectancy of at least 6 months

   6. Adequate bone marrow function as described in the protocol

   7. Adequate organ function as described in the protocol

   8. Willingness to undergo mandatory tumor biopsy pretreatment, if in the opinion of the
   investigator, the patient has an accessible lesion that can be biopsied without
   significant risk to the patient.

   9. Willing and able to comply with clinic visits and study-related procedures

10. Provide signed informed consent or legally acceptable representative

Key Exclusion Criteria:

   1. Primary central nervous system (CNS) lymphoma or known or suspected CNS involvement by
   non-primary CNS NHL

   2. History of or current relevant CNS pathology such as

      - Epilepsy, seizure, paresis, aphasia, apoplexia, severe brain injuries, cerebellar
      disease, organic brain syndrome, psychosis, or

      - Evidence for presence of inflammatory lesions and/or vasculitis on cerebral MRI

   3. Standard anti-lymphoma chemotherapy (non-biologic) or radiotherapy within 28 days
   prior to first administration of study drug

   4. Infection with human immunodeficiency virus (HIV) or chronic infection with hepatitis
   B virus (HBV), hepatitis C virus (HCV), or cytomegalovirus (CMV) infection [(as noted
   by detectable levels on a blood polymerase chain reaction (PCR) assay)].

      1. Patients with hepatitis B (HepBsAg+) who have controlled infection (serum
      hepatitis B virus deoxyribonucleic acid (DNA) that is below the limit of
      detection AND receiving anti-viral therapy for hepatitis B) are permitted upon
      consultation with the physician managing the infection.

      2. Patients who show detectable levels of CMV at screening will need to be treated
      with appropriate antiviral therapy and demonstrate at least 2 undetectable levels
      of CMV by PCR assay (at least 7 days apart) before being re-considered for
      eligibility.

   5. Patients who have received a live vaccination within 28 days of first dose of study
   treatment

Note: Other protocol Inclusion/Exclusion criteria apply