Trial Search Results

Effect of Celiac Plexus Block on Gastric Emptying and Symptoms Caused by Gastroparesis

The investigators hypothesize that in patients with gastroparesis, gastric emptying will improve with celiac plexus block. By improving gastric emptying, symptoms related to gastroparesis including nausea, vomiting, bloating, abdominal pain, and weight loss, will also improve.

In order to study this hypothesis, the investigators will enroll patients with gastroparesis who are non-responsive to the current treatments available. Patients will fill out a questionnaire to assess the severity of their symptoms then undergo Ansar testing (a non-invasive test) to measure their autonomic function respectively. Then, patients will undergo a celiac plexus block which is performed via an upper endoscopy. One week after the procedure, patients will be asked to undergo a gastric emptying study as well as repeat the Ansar testing to evaluate for any improvement in the gastric emptying and autonomic function respectively. Patient will be asked to repeat the questionnaire, one, two, three, and eight weeks after their procedure.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Linda Nguyen

Collaborator: Stanford University

Stanford Investigator(s):


  • Procedure: Celiac Plexus Block




Inclusion Criteria:

   - Patients must have gastroparesis due to idiopathic causes (including post-viral) and
   diabetes who have undergone a 4 hour gastric emptying study showing delayed gastric

   - Patients may have been or currently on therapy for their gastroparesis including
   metoclopramide, domperidone, macrolide antibiotics, sapropterin dihydrochloride, or
   pyloric botox injections can be included

   - Patients who have undergone placement of electrical gastric stimulator >6 months after
   enrollment can be included

Exclusion Criteria:

   - Patients with suspected mechanical obstruction resulting in delayed gastric emptying,
   patients chronically using narcotics (>3 times per week)

   - Patients who have undergone placement of gastric electrical stimulation device within
   6 months of enrollment.

   - Patients with any history of small bowel obstruction and major abdominal surgeries
   (excluding appendectomy, cholecystectomy, Nissen fundoplication, or pelvic surgeries).

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Irene Sonu, MD
Not Recruiting