Trial Search Results

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

National Cancer Institute (NCI)

Stanford Investigator(s):


  • Drug: Adavosertib
  • Drug: Afatinib
  • Drug: Afatinib Dimaleate
  • Drug: Binimetinib
  • Drug: Capivasertib
  • Drug: Copanlisib
  • Drug: Copanlisib Hydrochloride
  • Drug: Crizotinib
  • Other: Cytology Specimen Collection Procedure
  • Drug: Dabrafenib
  • Drug: Dabrafenib Mesylate
  • Drug: Dasatinib
  • Drug: Defactinib
  • Drug: Defactinib Hydrochloride
  • Drug: Erdafitinib
  • Drug: FGFR Inhibitor AZD4547
  • Drug: Ipatasertib
  • Other: Laboratory Biomarker Analysis
  • Drug: Larotrectinib
  • Drug: Larotrectinib Sulfate
  • Biological: Nivolumab
  • Drug: Osimertinib
  • Drug: Palbociclib
  • Biological: Pertuzumab
  • Drug: PI3K-beta Inhibitor GSK2636771
  • Drug: Sapanisertib
  • Drug: Sunitinib Malate
  • Drug: Taselisib
  • Drug: Trametinib
  • Biological: Trastuzumab
  • Biological: Trastuzumab Emtansine
  • Drug: Ulixertinib
  • Drug: Vismodegib


Phase 2


Inclusion Criteria:


   - Women of childbearing potential must have a negative serum pregnancy test within 2
   weeks prior to registration; patients that are pregnant or breast feeding are
   excluded; a female of childbearing potential is any woman, regardless of sexual
   orientation or whether they have undergone tubal ligation, who meets the following

      - Has not undergone a hysterectomy or bilateral oophorectomy; or

      - Has not been naturally postmenopausal for at least 24 consecutive months (i.e.,
      has had menses at any time in the preceding 24 consecutive months)

   - Women of childbearing potential and men must agree to use adequate contraception
   (hormonal or barrier method of birth control; abstinence) prior to study entry, for
   the duration of study participation, and for 4 months after completion of study;
   should a woman become pregnant or suspect while she or her partner is participating in
   this study, she should inform her treating physician immediately

   - Patients must have histologically documented solid tumors or histologically confirmed
   diagnosis of lymphoma or multiple myeloma requiring therapy and meet one of the
   following criteria:

      - Patients must have progressed following at least one line of standard systemic
      therapy and there must not be other approval/standard therapy available that has
      been shown to prolong overall survival (i.e. in a randomized trial against
      another standard treatment or by comparison to historical controls); patients who
      cannot receive other standard therapy that has been shown to prolong overall
      survival due to medical issues will be eligible, if other eligibility criteria
      are met; if the patient is currently receiving therapy, the clinician must have
      assessed that the current therapy is no longer benefitting the patient prior to
      enrolling on MATCH, regardless of whether it is considered standard OR

      - Patients for whose disease no standard treatment exists that has been shown to
      prolong overall survival

      - NOTE: No other prior malignancy is allowed except for the following:

      - Adequately treated basal cell or squamous cell skin cancer

      - In situ cervical cancer

      - Adequately treated stage I or II cancer from which the patient is currently in
      complete remission

      - Any other cancer from which the patient has been disease-free for 5 years

   - Patients must have measurable disease

   - Patients must meet the criteria below and have received results from one of the
   designated outside laboratories indicating a "rare variant" that is an actionable
   Mutation of Interest (aMOI) for specific select subprotocols.

      - The following requirements apply:

         - The outside laboratory specifically notified the site that patient may be a
         potential candidate for MATCH due to a detected "rare variant"; the outside
         lab reports are NOT sufficient for this purpose

            - NOTE: The content and format of these specific notifications for the
            Outside Assay process will vary depending on the designated outside lab
            in question, as they are each responsible for their own outreach
            efforts; it is strongly recommended that the designated outside
            laboratory be contacted to confirm the format and receipt of this
            notification prior to registering any patients to Step 0

         - Patients with an applicable "rare variant" must be able to meet the
         eligibility criteria for the appropriate subprotocols within 4 weeks
         following notification of treatment assignment

            - NOTE: The receipt of this notification (and the start of the associated
            deadline for Step 1 registration) may occur shortly after Step 0
            registration, since these patients will not be submitting tissue for
            screening purposes; however, for certain "rare variant" arms,
            submission of archival tissue for central immunohistochemistry (IHC)
            testing may be required

         - Registration to Step 0 must occur after stopping prior systemic anti-cancer
         therapy; there is no specific duration for which patients must be off
         treatment prior to registration to Step 0, as long as all eligibility
         criteria are met

         - There is no particular window of time after notification of potential
         eligibility from an outside lab in which the patient must be registered to
         Step 0, but treatment slots will be assigned on a first come, first serve
         basis to those who do register to Step 0, and are not held for those
         notified of potential eligibility who do not register to Step 0

         - Patients may have received other non-targeted, immunotherapy or targeted
         treatment between the prior genetic testing at the outside lab and
         registration to Step 0; the decision to stop such treatment in favor of
         participation in MATCH, if no further clinical benefit is expected, is per
         the treating physician's discretion; documentation of a lack of response to
         the prior treatment is not required in these cases

            - NOTE: Other potential aMOIs that would be eligibility criteria for "NON
            RARE" arms, as determined by the designated laboratories, are not
            applicable for this process in MATCH

            - NOTE: Tumor tissue for the confirmation of "rare variant" by the MATCH
            assay is to be submitted, preferably from the same time of collection
            as that evaluated by the designated outside laboratory

   - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< 1
   and a life expectancy of at least 3 months

   - Patients must be able to swallow tablets or capsules; a patient with any
   gastrointestinal disease that would impair ability to swallow, retain, or absorb drug
   is not eligible

   - Patients who are human immunodeficiency virus (HIV)-positive are eligible if:

      - CD4+ cell count greater or equal to 250 cells/mm^3

      - If patient is on antiretroviral therapy, there must be minimal interactions or
      overlapping toxicity of the antiretroviral therapy with the experimental cancer
      treatment; for experimental cancer therapeutics with CYP3A/4 interactions,
      protease inhibitor therapy is disallowed; suggested regimens to replace protease
      inhibitor therapy include dolutegravir given with tenofovir/emtricitabine;
      raltegravir given with tenofovir and emtricitabine; once daily combinations that
      use pharmacologic boosters may not be used

      - No history of non-malignancy acquired immune deficiency syndrome (AIDS)-defining
      conditions other than historical low CD4+ cell counts

      - Probable long-term survival with HIV if cancer were not present

   - Any prior therapy, radiotherapy (except palliative radiation therapy of 30 gray [Gy]
   or less), or major surgery must have been completed >= 4 weeks prior to start of
   treatment; all adverse events due to prior therapy have resolved to a grade 1 or
   better (except alopecia and lymphopenia) by start of treatment; palliative radiation
   therapy must have been completed at least 2 weeks prior to start of treatment; the
   radiotherapy must not be to a lesion that is included as measurable disease

      - NOTE: Prostate cancer patients may continue their luteinizing hormone-releasing
      hormone (LHRH) agonist

      - NOTE: For patients entering the study via the original screening process,
      patients may receive non-protocol treatment after biopsy (if clinically
      indicated) until they receive notification of results; however, lack of response
      must be documented prior to registration to Step 1; new non-protocol treatment
      will NOT be permitted as intervening therapy after registration to Step 0; the
      only intervening treatment permitted is prior therapy that the patient already
      received prior to Step 0 registration; the decision to stop the intervening
      non-protocol treatment will be left up to the treating physician if patient has
      an aMOI; however, patients will need to be off such therapy for at least 4 weeks
      before receiving any MATCH protocol treatment

      - NOTE: For patients entering the study via a designated outside laboratory, no
      intervening systemic non-protocol treatment is permitted after Step 0
      registration; all other eligibility requirements still apply to these patients,
      including the washouts for prior therapy noted above in this section, the time
      restrictions outlined, and the eligibility criteria for the intended subprotocol

   - Patients with brain metastases or primary brain tumors must have completed treatment,
   surgery or radiation therapy >= 4 weeks prior to start of treatment

   - Patients must have discontinued steroids >= 1 week prior to registration to Step 0 and
   remain off steroids thereafter, except as permitted; patients with glioblastoma (GBM)
   must have been on stable dose of steroids, or be off steroids, for one week prior to
   registration to treatment (Step 1, 3, 5, 7)

      - NOTE: The following steroids are permitted (low dose steroid use is defined as
      prednisone 10 mg daily or less, or bioequivalent dose of other corticosteroid):

         - Temporary steroid use: e.g. for computed tomography (CT) imaging in setting
         of contrast allergy

         - Low dose steroid use for appetite

         - Chronic inhaled steroid use

         - Steroid injections for joint disease

         - Stable dose of replacement steroid for adrenal insufficiency or low doses
         for non-malignant disease

         - Topical steroid

         - Steroids required to manage toxicity related to study treatment, as
         described in the subprotocols

         - Steroids required as pre- or post-chemotherapy medication for acceptable
         intervening chemotherapy

            - NOTE: Steroids must be completed alongside last dose of chemotherapy

   - Leukocytes >= 3,000/mcL (within 2 weeks prior to screening step registration and
   within 4 weeks prior to treatment step registration)

   - Absolute neutrophil count >= 1,500/mcL (within 2 weeks prior to screening step
   registration and within 4 weeks prior to treatment step registration)

   - Platelets >= 100,000/mcL (within 2 weeks prior to screening step registration and
   within 4 weeks prior to treatment step registration)

   - NOTE: Patients with documented bone marrow involvement by lymphoma are not required to
   meet the above hematologic parameters, but must have a platelet count of at least
   75,000/mcL and neutrophil count of at least 1,000/mcL

   - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (unless documented
   Gilbert's syndrome, for which bilirubin =< 3 x institutional ULN is permitted) (within
   2 weeks prior to screening step registration and within 4 weeks prior to treatment
   step registration)

   - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
   [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
   =< 2.5 x institutional ULN (up to 5 times ULN in presence of liver metastases) (within
   2 weeks prior to screening step registration and within 4 weeks prior to treatment
   step registration)

   - Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above
   institutional normal

      - As defined by the Cockcroft-Gault equation (within 2 weeks prior to screening
      step registration and within 4 weeks prior to treatment step registration)

   - Patients must have an electrocardiogram (ECG) within 8 weeks prior to registration to
   screening step and must meet the following cardiac criteria:

      - Resting corrected QT interval (QTc) =< 480 msec

         - NOTE: If the first recorded QTc exceeds 480 msec, two additional,
         consecutive ECGs are required and must result in a mean resting QTc =< 480
         msec; it is recommended that there are 10-minute (+/- 5 minutes) breaks
         between the ECGs

      - The following only need to be assessed if the mean QTc > 480 msec

         - Check potassium and magnesium serum levels

         - Correct any identified hypokalemia and/or hypomagnesemia and may repeat ECG
         to confirm exclusion of patient due to QTc

         - For patients with heart rate (HR) 60-100 beats per minute (bpm), no manual
         read of QTc is required

         - For patients with baseline HR < 60 or > 100 bpm, manual read of QT by
         trained personnel is required, with Fridericia correction applied to
         determine QTc

         - Patient must not have hypokalemia (value < institutional lower limit of

      - No factors that increase the risk of QTc prolongation or risk of arrhythmic
      events such as heart failure, congenital long QT syndrome, family history of long
      QT syndrome or unexplained sudden death under 40 years of age or any concomitant
      medication known to prolong the QT interval

         - NOTE: Patient must be taken off prohibited medication prior to registration
         to the screening step (Step 0, 2, 4, 6) and remain off these medications
         thereafter, unless permitted on a subprotocol for the management of
         treatment related toxicity; patient must be off the drug for at least 5
         half-lives prior to registration to the treatment step (Step 1, 3, 5, 7);
         the medication half-life can be found in the package insert for Food and
         Drug Administration (FDA) approved drugs


   - If patients have been biopsied or submitted archived tumor tissue obtained within the
   last 6 months for assessment with the MATCH assays, patients may receive non-protocol
   treatment after biopsy/tissue submission (if clinically indicated) until they receive
   notification of results however, lack of response must be documented prior to
   registration to step 1; new non-protocol treatment will NOT be permitted as
   intervening therapy after registration to Step 0; for patients entering step 0 with
   assay results from outside laboratories, no systemic treatment is allowed after step 0
   registration; the decision to stop the intervening nonprotocol treatment will be left
   up to the treating physician if patient has an aMOI; waiting periods as described will

   - As MATCH is designed to add additional subprotocols, implement limited expansions of
   accrual for certain subprotocols, and/or amend existing arm-specific eligibility
   criteria, some patients entering under the original screening method may be eligible
   to have their results rerun in MATCHbox, even if they did not match to a treatment
   initially or did not receive a treatment assignment due to a lack of available
   assignment slots; patients whose sequence results will be rerun through MATCHbox must
   also meet the following criteria:

      - Samples must have been collected within 5 months of the activation of the
      addendum, as there is an additional month needed to get the patients on trial

      - Patient has not had treatment within the 5 months that resulted in a PR or better
      after the performance of the screening assessment

      - Patient must meet eligibility criteria, including performance status 1 or better
      and life expectancy of at least 3 months

      - Patients must meet the eligibility requirements with the following exceptions:

         - Patients may have received other non-targeted, immunotherapy or targeted
         treatment, which could be stopped in favor of returning to MATCH, if no
         response to the interim treatment has occurred and no further benefit is
         expected from this interim treatment, per the treating physician's
         discretion; documentation o

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Ivy Lau