Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy

Inclusion Criteria: Unless specified otherwise, ocular specific inclusion criteria apply to
the study eye only.

   1. Male or Female.

   2. Age greater than or equal to 50 years.

   3. BCVA of 20/320 (Snellen equivalent) or better using ETDRS charts.

   4. Diagnosis of GA of the macula secondary to age-related macular degeneration, confirmed
   within 14 days prior to randomization by the central reading center (CRC) using Fundus
   Autofluorescence (FAF) images, as well as the following criteria:

      1. Total GA area must be ≥ 2.5 and ≤ 17.5 mm2 (1 and 7 disk areas [DA]
      respectively), determined by screening images of FAF.

      2. If GA is multifocal, at least one focal lesion must be ≥ 1.25 mm2 (0.5 DA).

      3. GA can be completely visualized on the macula centered image.

      4. GA must be able to be photographed in its entirety.

      5. GA must be able to be measured separately from any areas of peripapillary atrophy
      as assessed by the CRC.

      6. Presence of any pattern of hyperautofluorescence in the junctional zone of GA.
      Absence of hyperautoflouorescence (i.e. pattern = none) is exclusionary. See Holz
      et al. 2007.1

   5. Female subjects must be:

      1. Women of non-child-bearing potential (WONCBP), or

      2. Women of child-bearing potential (WOCBP) with a negative pregnancy test at
      screening and must agree to use protocol defined methods of contraception for the
      duration of the study.

   6. Males with female partners of child-bearing potential must agree to use protocol
   defined methods of contraception and agree to refrain from donating sperm for the
   duration of the study.

   7. Willing and able to give informed consent.

Exclusion Criteria: Unless specified otherwise, ocular specific inclusion criteria apply to
the study eye only.

   1. GA due to causes other than AMD such as Stargardt disease, cone rod dystrophy or toxic
   maculopathies like plaquenil maculopathy.

   2. Spherical equivalent of the refractive error demonstrating > 6 diopters of myopia or
   an axial length >26 mm.

   3. Any history or current evidence of exudative ("wet") AMD including any evidence of
   retinal pigment epithelium rips or evidence of neovascularization anywhere in the
   retina based on fluorescein angiogram as assessed by the CRC.

   4. Retinal disease other than AMD; however, benign conditions of the vitreous or
   peripheral retina are not exclusionary (i.e. pavingstone degeneration).

   5. Any ophthalmologic condition that reduces the clarity of the media and that, in the
   opinion of the Investigator interferes with ophthalmologic examination (e.g. advanced
   cataract or corneal abnormalities).

   6. Any ophthalmologic condition that prevents adequate imaging of the retina judged by
   the site or CRC.

   7. Intraocular surgery (including lens replacement surgery) within 3 months prior to
   randomization.

   8. Aphakia or absence of the posterior capsule. Previous violation of the posterior
   capsule is also excluded unless it occurred as a result of yttrium aluminum garnet
   (YAG) laser posterior capsulotomy in association with prior posterior chamber
   intraocular lens implantation and at least 60 days prior to Day 0.

   9. Any ophthalmic condition that may require surgery during the study period.

10. Any contraindication to IVT injection including current ocular or periocular
   infection.

11. History of uveitis or endophthalmitis.

12. History of IVT injection at any time.

13. Participation in another interventional clinical study, or use of any experimental
   treatment for AMD or any other investigational new drug within 6 weeks or 5 half-lives
   of the active (whichever is longer) prior to the start of study treatment. Note:
   clinical trials solely involving observation, over-the-counter vitamins, supplements,
   or diets are not exclusionary.

14. Medical or psychiatric conditions that, in the opinion of the investigator, make
   consistent follow-up over the treatment period unlikely, or in general a poor medical
   risk because of other systemic diseases or active uncontrolled infections.

15. Any screening laboratory value (hematology, serum chemistry or urinalysis) that in the
   opinion of the Investigator is clinically significant and not suitable for study
   participation.

16. Hypersensitivity to fluorescein.