Trial Search Results

Non-Damaging Photothermal Therapy of Non-exudative Age Related Macular Degeneration

This is a randomized controlled study of non-damaging photothermal macular grid laser versus sham laser therapy in patients with dry age-related macular degeneration (AMD) and large high-risk drusen. The goal of the study is to determine if this treatment will reduce macular drusen volume and also whether this might improve visual acuity or reduce the risk of conversion to advanced age-related macular degeneration defined as development of choroidal neovascularization or geographic atrophy.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Bascom Palmer Eye Institute

Stanford Investigator(s):

Intervention(s):

  • Device: macular laser treatment
  • Device: sham macular laser treatment

Phase:

N/A

Eligibility


Inclusion Criteria

   1. Older than 60 years of age.

   2. Male or female patients with nonexudative AMD with a drusen volume of of at least
   0.03mm3 in the central 3mm circle

   3. Adequate pupil dilatation and clear media to perform colour, red-free imaging and
   fundus fluorescein angiography, fundus autofluorescence imaging and OCT.

   4. Able to give an informed consent.

Exclusion Criteria:

   1. Presence of signs of advanced AMD, such as CNV, haemorrhages or macular atrophy based
   on OCT and fundus autofluorescence photography (FAF).

   2. Previous macular laser treatment.

   3. Any previous ocular condition that may be associated with a risk of developing macular
   oedema.

   4. Vitreomacular traction determined clinically and /or by OCT, which in the opinion of
   the investigator, contributes to the macular oedema (associated or causing a
   detachment of the fovea).

   5. Presence of other macular disease such as epiretinal membrane, macular telangiectasia.

   6. Important known allergies to sodium fluorescein dye used in angiography.

   7. Ocular or periocular infections.

   8. Planned intra-ocular surgery within one year.

   9. Patient is unavailable for follow-up visits.

Ages Eligible for Study

60 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Mariana Nunez
650-497-7846