Trial Search Results

Cross-linking for Corneal Ulcers Treatment Trial

The primary purpose of this study is to determine if patients randomized to corneal collagen cross-linking plus medical therapy will have a lower prevalence of positive bacterial or fungal cultures immediately after the procedure than patients who received medical therapy alone.

The secondary purpose of this study is to determine if patients randomized to corneal collagen cross-linking will have a better visual acuity at 3 and 12 months than patients who receive medical therapy alone.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

University of California, San Francisco

Collaborator: Aravind Eye Hospitals, India

Stanford Investigator(s):

Intervention(s):

  • Procedure: Bacterial ulcer cross-linking
  • Procedure: Bacterial ulcer control
  • Procedure: Fungal ulcer cross-linking
  • Procedure: Fungal ulcer control

Phase:

Phase 4

Eligibility


Inclusion criteria:

   - Corneal ulcer that is smear positive for either bacteria or filamentous fungus

   - Pinhole visual acuity worse than 20/70 in the affected eye

   - Not treated already with antimicrobial medications at presentation

   - Age over 18 years

   - Basic understanding of the study as determined by the physician

   - Commitment to return for follow up visits

Exclusion criteria:

   - Evidence of concomitant infection on exam or gram stain (i.e. herpes, both bacteria
   and acanthamoeba on gram stain)

   - Impending or frank perforation at recruitment

   - Involvement of sclera at presentation

   - Non-infectious or autoimmune keratitis

   - History of corneal transplantation or recent intraocular surgery

   - No light perception in the affected eye

   - Pinhole visual acuity worse than 20/200 in the unaffected eye

   - Participants who are decisionally and/or cognitively impaired

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Recruiting