Assessment of Catheter-based Interrogation and Standard Techniques for Fractional Flow Reserve Measurement

General Inclusion Criteria:

   - Subject is 18 years of age or older

   - Subject has a clinical indication for coronary angiography

   - Subject or subject's legal representative has the ability to understand and provide
   signed consent for participating in the study

Angiographic Inclusion Criteria:

   - Vessel has a TIMI flow = 3

   - Subject has de novo lesion which physician has determined has a clinical indication
   for FFR measurement

   - RVD of the target lesion is assessed by the operator to be ≥2.25 mm.

General Exclusion Criteria:

   - Subjects with acute ST-elevation or non-ST-elevation myocardial infarction as the
   indication for coronary angiography

   - NYHA Class 4 severe heart failure

Angiographic Exclusion Criteria:

   - Target vessel has angiographically visible or suspected thrombus.

   - Target lesion is within a bypass graft.

   - Angiographic evidence of a dissection prior to initiation of PW measurements.

   - Target vessel contains excessive tortuosity or calcification.