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68Ga-PSMA-11 PET/MRI in Finding Tumors in Patients With Intermediate or High-Risk Prostate Cancer Undergoing Surgery
Not Recruiting
Trial ID: NCT02678351
Purpose
This phase 2-3 trial studies the utility of 68-gallium (68Ga)-prostate-specific membrane
antigen 11 (PSMA-11) positron emission tomography/magnetic resonance imaging (PET/MRI) to
find tumors in patients with prostate cancer who are undergoing resection surgery for
prostate cancer that is prognostically expected to spread quickly (intermediate-risk) or is
likely to come back or spread (high-risk). Diagnostic procedures, such as PET/MRI, may help
find and diagnose prostate cancer, and reveal out how far the disease has spread. Radioactive
drugs, such as 68Ga-PSMA-11, may bind to tumor cells that have specific receptors, and may
allow doctors to see smaller tumors than the standard of care contrast-enhanced computed
tomography (CT) or MRI scan.
Official Title
68Ga-PSMA-11 PET/MRI for Detection of Regional Nodal and Distant Metastases in Patients With Intermediate and High-Risk Prostate Cancer
Stanford Investigator(s)
Andrei Iagaru
Professor of Radiology (Nuclear Medicine)
Eligibility
INCLUSION CRITERIA
- Biopsy-proven prostate adenocarcinoma
- Planned prostatectomy with lymph node dissection
- Intermediate- to high-risk disease (as determined by elevated prostate-specific
antigen (PSA) [PSA > 10], T stage [T2b or greater], Gleason score [Gleason score > 6]
or other risk factors)
- Karnofsky performance status of ≥ 50 [or Eastern Cooperative Oncology Group
(ECOG)/World Health Organization (WHO) equivalent]
- Diagnostic CT or MRI performed within 90 days of the research PET
- Able to provide written consent
ExCLUSION CRITERIA
- Patients not capable of getting PET study due to weight, claustrophobia, or inability
to lay still for the duration of the exam
- Neoadjuvant chemotherapy or radiation therapy prior to prostatectomy, including focal
ablation techniques (HiFu)
- Androgen deprivation therapy or other neoadjuvant treatments prior to PET imaging and
surgery
- Metallic implants (contraindicated for MRI)
Intervention(s):
drug: 68Ga-PSMA-11
procedure: Magnetic resonance imaging (MRI)
procedure: Positron Emission Tomography (PET)
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Pranav Hegde
650-721-4080