Trial Search Results

Neuroblastoma Precision Trial

This proposal sets forth the platform for a Precision Medicine clinical trial through the New Approaches to Neuroblastoma Therapy (NANT) consortium. We plan to utilize NANT's established multi-institutional infrastructure and Translational Genomics Research Institute (TGen) GEMTM sequencing platform for acquisition and gene panel sequencing of relapsed biological specimens in rNB including those obtained from the bone, bone marrow or soft tissue.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

New Approaches to Neuroblastoma Therapy Consortium

Collaborator: Rising Tide Foundation

Stanford Investigator(s):

Intervention(s):

  • Other: Gene panel sequencing of tumor specimens

Eligibility


Inclusion Criteria:

   - Patients must be ≥ 1 year and ≤ 30 years of age at study registration

   - Patients must have had a diagnosis of neuroblastoma either by histological
   verification of neuroblastoma and/or demonstration of tumor cells in the bone marrow
   with increased urinary catecholamines.

   - Patients must have a history of high-risk neuroblastoma according to

   - COG risk classification at the time of study registration. Patients must have at least
   one of the following: Recurrent/progressive disease, Refractory disease, Persistent
   disease

   - Patient must be willing to undergo a clinically indicated biopsy and meet at least one
   of the following requirements: Bone biopsy, Soft tissue biopsy, Bone marrow biopsy and
   aspirate

   - Patients must not be receiving any other anti-cancer agents or radiotherapy during the
   interval

Exclusion Criteria:

   - Patients with disease of any major organ system that would compromise their ability to
   withstand biopsy procedures of soft tissue, bone and/or bone marrow.

   - Patients who enroll and successfully receive a NANT Precision Report may not re-enroll
   at a future time.

   - Patient declines participation in NANT 2004-05, the NANT Biology Study.

Ages Eligible for Study

1 Year - 30 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
CCTO
650-499-7061
Not Recruiting