©2022 Stanford Medicine
Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
Recruiting
I'm InterestedTrial ID: NCT02889016
Purpose
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by
the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction
accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include
anxiety, emotional lability, depression, irritability, aggression, oppositionality,
deterioration in school performance, behavioral (developmental) regression, sensory
amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is
thought to be caused by infection, inflammation, or alternate triggers that is associated
with a brain response that leads to these symptoms. The purpose of this study is to examine
specific neurologic, immunologic, rheumatologic, and genomic, components in children with the
acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story
of autoimmune processes that are involved in psychiatric disorders of childhood. By better
understanding the etiologic components of psychiatric phenomenon, future treatments may be
better targeted to underlying causes.
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
- Children with PANS
1. Age 1-18 at onset of PANS
2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of
the following associated symptoms: frequent urination, worsening
handwriting/cognition, inattention, anorexia, separation anxiety,
oppositionality, irritability/rage outbursts, and emotional lability.
3. Patients must live within 90 miles of Stanford University and have a new onset of
PANS illness
4. Patients must have an established pediatrician within 90 miles of Stanford
University for 3 years.
- Healthy Controls
1. Age 4-18
2. No psychiatric diagnosis
Exclusion Criteria:
- Any neuropsychiatric illness that may obscure the clear diagnosis of PANS
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Joanne Cheung