Multi OIT to Test Immune Markers After Minimum Maintenance Dose

Inclusion Criteria:

   - Aged 2 to 25 years with clinical history of allergy to at least two of the following:
   milk and/or egg and/or peanut and/or almond and/or wheat and/or cashew and/or sesame
   seed and/or soy and/or pecan and/or walnut and/or hazelnut and/or shrimp and/or cod
   and/or salmon and

   - Sensitivity to food allergens documented by a positive skin prick test result greater
   than or equal to 6mm wheal diameter to each allergen or

   - ImmunoCAP IgE level >4kU/L for each allergen and

   - If female of child bearing potential, a negative urine pregnancy test before being
   allowed to participate in the study (week 0) and

   - A plan to remain in the study area of the research center during the trial and

   - Be trained on the proper use of the Epinephrine autoinjector and agree to follow epi
   training to be allowed to enroll in the study and

   - If female of child-bearing potential, willing to be compliant with a
   medically-approved method of contraception (please see Pregnancy section in this IND
   document) and

   - Agree to eliminate other known food allergens from subject's diet so as not to
   confound the safety and efficacy data from the study and

   - Avoid open or blinded food challenges to food allergens

Exclusion Criteria:

   - Previous anaphylactic reaction to Omalizumab

   - A history of severe anaphylaxis to food allergens that will be desensitized in this
   study requiring intubation or admission to an ICU, frequent allergic or non-allergic
   urticaria, or history consistent with poorly controlled persistent asthma

   - Unstable angina, significant arrhythmia, uncontrolled hypertension, chronic sinusitis,
   or other chronic or immunological diseases that, in the judgment of the investigator,
   might interfere with the evaluation or administration of the test drug or pose
   additional risk to the subject (e.g., gastrointestinal or gastroesophageal disease,
   chronic infections, scleroderma, hepatic and gallbladder disease, chronic non-allergic
   pulmonary disease)

   - An average forced expiratory volume at one second (FEV1) or peak expiratory flow rate
   (PEF) less than 80% predicted (moderate persistent asthma) with or without controller
   medication (if able to perform the maneuver) at screening, or a food challenge visit

   - Current users of oral, intramuscular, or intravenous corticosteroids, tricyclic
   antidepressants, or are taking a beta-blocker (oral or topical)

   - Routinely using medication that could induce adverse gastrointestinal reactions during
   the study

   - Refusing to sign or follow the Epinephrine autoinjector Training Form

   - Pregnant or breast feeding women

   - Unwilling to avoid other allergens outside this study

   - Concurrent/prior use of immunomodulatory therapy (within 6 months)

   - A diagnosis of eosinophilic esophagitis, eosinophilic colitis, or eosinophilic
   gastritis.