Trial Search Results

The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging

Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to meet the increased work requirement. Several, interconnected adaptive mechanisms have been proposed, including myocyte hypertrophy, a switch in the primary fuel used for ATP generation, increased angiogenesis, and decreased production of mitochondrial reactive oxygen species. While adaptation is initially successful in many cases, it is temporary, and after an uncertain period of time, the ventricle begins to fail. This transition from a compensated to decompensated state is difficult to predict clinically, and patients with different etiologies of CPOS progress to overt RV failure over significantly different time periods. This variability hinders the implementation of treatments that are tailored to a specific disease stage.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Centre Chirurgical Marie Lannelongue

Stanford Investigator(s):

Intervention(s):

  • Procedure: Right ventricular biopsies

Phase:

N/A

Eligibility


-Inclusion Criteria:

Chronic thromboembolic pulmonary hypertension group:

   - Patients undergoing pulmonary endarterectomy at Marie Lannelongue Surgical Center for
   the treatment of chronic thromboembolic pulmonary hypertension.

Control group:

   - Patients undergoing adult cardiac surgery without evidence of pulmonary hypertension
   on preoperative assessment

   - Exclusion Criteria:

Chronic thromboembolic pulmonary hypertension group:

   - Insufficient biopsy material,

   - pre-operative therapy with bosentan or sildenafil

Control group:

   - Insufficient biopsy sample,

   - ischemic cardiomyopathy,

   - miral or tricuspid valve disease,

   - pre-operative pulmonary hypertension.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting