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Improving Cognition Via Exercise in Schizophrenia
Not Recruiting
Trial ID: NCT03270098
Purpose
People with schizophrenia display a broad range of cognitive impairments that have been
identified as major determinants of poor functioning and disability. Also, people with
schizophrenia are at increased risk for suicide, with approximately 40-50% of individuals
attempting to take their own lives during their lifetime. The goal of the proposed study is
to examine the impact of remote exercise training on cognition, suicide risk, daily
functioning, and biomarkers of cognitive change and suicidality in people with schizophrenia.
Official Title
Improving Cognition Via Exercise in Schizophrenia
Stanford Investigator(s)
Jacob S. Ballon
Associate Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology)
Melanie Lean
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
Khalid Salaheldin, MD
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
Eligibility
Inclusion Criteria:
- A DSM-V diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder.
- Age 18-55 years.
- Taking antipsychotic medication for at least 8 weeks and on current doses for 4 weeks,
and/or injectable depot antipsychotics with no change in the last 3 months.
- Capacity to understand all the potential risks and benefits of the study.
- Medically cleared by a physician to take part in VO2max tests and aerobic exercise
training or stretching-and-toning exercise training.
Exclusion Criteria:
- A DSM-V diagnosis of alcohol/substance abuse (except nicotine) within the last month
or a diagnosis of alcohol/substance dependence (except nicotine) within the last 6
months
- Initiation of anti-depressants, mood stabilizers, or other medications known to impact
cognition in previous 4 weeks or any change in doses during this period.
- History of seizures/head trauma with loss of consciousness (>10 minutes) resulting in
cognitive sequelae.
- Significant clinical abnormalities in physical examination, lab assessments, or ECG.
- Neurological/medical conditions that could interfere with study participation (e.g.,
unstable cardiac disease, stuttering).
- Body Mass Index (BMI) ≥ 40.
- Untreated hyper- or hypothyroidism.
- Being pregnant or nursing.
- Serious homicidal/suicidal risk (past 6 months).
- "Moderate" or more severe conceptual disorganization (PANSS≥4).
- Poor English reading ability (WTAR<7).
- Participation in a study with cognitive assessment in the past 3 months.
- Serious homicidal risk (past 6 months)
Intervention(s):
behavioral: Aerobic Exercise
behavioral: Stretching and Toning Exercise
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Daniel Virtheim
650-353-7030