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Platelet Rich Plasma for Patients With Recurrent Implantation Failure
Not Recruiting
Trial ID: NCT03379649
Purpose
Patients with recurrent implantation failure are among the most difficult patients to treat,
with no proven standard treatment. Platelet rich plasma stimulates cellular processes
involved in endometrial regeneration, and in a small case series has shown efficacy for this
patient population. We hope to conduct a randomized controlled pilot study to determine
whether PRP is indeed an effective treatment for recurrent implantation failure.
Official Title
Platelet Rich Plasma for Patients With Recurrent Implantation Failure: A Prospective Randomized Pilot Study
Stanford Investigator(s)
Lusine Aghajanova, M.D., Ph.D.
Clinical Associate Professor, Obstetrics & Gynecology - Reproductive Endocrinology & Infertility
Ruth Lathi, M.D.
Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility)
Eligibility
Inclusion Criteria:
- All women who have undergone 3 or more embryo (blastocyst stage) transfers without
establishing a clinical pregnancy or 2 or more euploid embryo transfers without
establishing a clinical pregnancy, aged 18 - 45, with a normal uterine cavity
established within 12 months by hysteroscopy or saline infusion sonogram, planning in
vitro fertilization with an embryo transfer at Stanford Fertility and Reproductive
Health. The planned transfer must consist of any of the following: a PGS proven
euploid embryo, a good quality blastocyst from a patient younger than 37, or a donor
oocyte blastocyst.
Exclusion Criteria:
- Abnormal uterine cavity, planning in vitro fertilization with use of a gestational
carrier. patients enrolled in other experimental interventions for RIF will be
excluded. Patients with only poor quality or cleavage stage embryos.
Intervention(s):
combination product: Platelet rich plasma
combination product: Placebo
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Jonathan D Kort, M.D.
650-498-7911