Trial Search Results
Topical Beremagene Geperpavec (KB103) Gene Therapy to Restore Functional Collagen VII for the Treatment of Dystrophic Epidermolysis Bullosa
This study is being conducted to determine if topical Beremagene Geperpavec (KB103, HSV1-COL7) can safely and effectively promote healing of DEB patient wounds (primary endpoint) and to assess change from baseline in Investigator Global Assessments and Patient Reported Outcomes (secondary endpoint).
Stanford is currently accepting patients for this trial.
Krystal Biotech, Inc.
- Biological: Topical beremagene geperpavec
- Clinical diagnosis of the recessive form of dystrophic epidermolysis bullosa.
1. 2 subjects: 18 years old or older,
2. 2 subjects: 5 years old or older.
- At least one wound that is between 10 and 20 cm2 in wound area.
- Subjects, who are, in the opinion of the Investigator, able to understand the study,
co-operate with the study procedures and are willing to return to the clinic for all
the required follow-up visit
- The presence of medical illness expected to complicate participation
- Serum antibodies to type collagen VII
- Active infection in the area that will undergo injection.
- Evidence of systemic infection.
- Current evidence or a history of squamous cell carcinoma in the area that will undergo
Ages Eligible for Study
5 Years - N/A
Genders Eligible for Study