Trial Search Results

The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients

Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health. This study will determine whether treatment with Tranexamic Acid (TXA), an FDA approved medication that reduces bleeding right after ACL injury and reconstructive surgery reduces inflammation and improves joint health as a new strategy to prevent or delay the onset of PTOA.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: United States Department of Defense

Stanford Investigator(s):


  • Drug: Tranexamic Acid
  • Drug: Placebos


Phase 2


Inclusion Criteria:

   - age 18-30 years

   - within 4 days of unilateral ACL injury

   - presence of effusion/hemarthrosis.

Exclusion Criteria:

   - inflammatory arthritis, radiographic osteoarthritis (K-L Grade 2 or higher), gout/

   - systemic or acute illness requiring medications

   - concomitant knee injury aside from meniscus tear and MCL tear not requiring surgery

   - prior surgery to either knee

   - prior injury to either knee requiring crutches

   - history of thromboembolic disease

   - current use of combination hormonal contraception

   - chronic NSAID use

   - cortisone injection to either knee within the prior 3 months

   - not indicated for or unable to undergo ACLR within 3 months of injury

Ages Eligible for Study

18 Years - 30 Years

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Christine Hoang