Trial Search Results

Interscalene Brachial Plexus Block Washout to Reverse Inadvertent Phrenic Nerve Blockade

One of the most frequently performed peripheral nerve blocks (the injection of local anesthetic near nerves to block sensation/ movement to a specific part of the body) is the interscalene brachial plexus block for upper extremity surgeries. This type of block can unmask underlying respiratory issues such as shortness of breath due to a well-known and typically insignificant side effect of temporary diaphragmatic paralysis.

The nerve block may be able to use saline solution to wash out the local anesthetic and potentially reverse this respiratory side effect. Specifically, the goal of this study is to determine if the injection of saline through the nerve block catheter reverses blockade of the phrenic nerve supplying the diaphragm, without affecting the ability of the nerve block to provide pain control after surgery.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):


  • Procedure: Normal saline injected via interscalene nerve catheter
  • Other: Placebo




Inclusion criteria:

   - All adult patients (18 years and over) scheduled for surgery requiring a continuous
   interscalene brachial plexus nerve block catheter as part of their anesthetic care.

Exclusion criteria:

   - Concomitant life-threatening injuries and other concomitant injuries causing
   significant pain

   - Pregnant

   - Any condition impairing patient's ability to consent to participation in study, and an
   existing condition contraindicating a nerve block, i.e. nerve injury, existing
   bleeding disorder, infection in the vicinity of the block, and patient refusal.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Lynn K Ngai, MD
Not Recruiting