SWAP-MEAT: Study With Appetizing Plant Food - Meat Eating Alternatives Trial

Inclusion Criteria:

   - Age ≥18

   - Meat consumption (beef, pork/sausage, chicken) on average ≥ once a day

   - Willing to consume meat (beef, pork/sausage, chicken) ≥ 2 times a day

Exclusion Criteria:

   - Weight < 110 lb

   - BMI ≥ 40

   - LDL-C >190 mg/dL

   - Systolic blood pressure (SBP) > 160 mmHg OR Diastolic blood pressure (DBP) > 90 mmHg

   - Use of any of the following drugs/supplements within the last 2 months:

      - systemic antibiotics, antifungals, antivirals or antiparasitics (intravenous,
      intramuscular, or oral);

      - corticosteroids (intravenous, intramuscular, oral, nasal or inhaled);

      - cytokines;

      - methotrexate or immunosuppressive cytotoxic agents;

   - Chronic, clinically significant, or unstable (unresolved, requiring on-going changes
   to medical management or medication) pulmonary, cardiovascular, gastrointestinal,
   hepatic or renal functional abnormality, as determined by medical history, Type 1
   diabetes, dialysis.

   - History of active cancer in the past 3 years except for squamous or basal cell
   carcinomas of the skin that have been medically managed by local excision.

   - Unstable dietary history as defined by major changes in diet during the previous
   month, where the subject has eliminated or significantly increased a major food group
   in the diet.

   - Recent history of chronic excessive alcohol consumption defined as more than five
   1.5-ounce servings of 80 proof distilled spirits, five 12-ounce servings of beer or
   five 5-ounce servings of wine per day; or > 14 drinks/week.

   - Any confirmed or suspected condition/state of immunosuppression or immunodeficiency
   (primary or acquired) including HIV infection, multiple sclerosis and Graves' disease.

   - Regular/frequent use of smoking or chewing tobacco, e-cigarettes, cigars or other
   nicotine-containing products.

   - Regular use of prescription opiate pain medication