Trial Search Results

A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis

The purpose of this study is to evaluate the safety and efficacy of elezanumab in participants with progressive Multiple Sclerosis (PMS).

Stanford is currently not accepting patients for this trial.

Lead Sponsor:


Stanford Investigator(s):


  • Drug: elezanumab
  • Drug: placebo


Phase 2


Inclusion Criteria:

   - Diagnosis of primary-progressive multiple sclerosis (PPMS) or non-relapsing
   secondary-progressive multiple sclerosis (SPMS) and no relapses for at least 24

   - Evidence of physical disability according to Expanded Disability Status Scale (EDSS)
   or Timed 25-Foot Walk (T25FW) or 9-Hole Peg Test.

Exclusion Criteria:

   - Treatment with any of the following within the 6 months prior to Screening:
   natalizumab; cyclosporine; azathioprine; methotrexate; mycophenolate mofetil;
   intravenous immunoglobulin (IVIg); any interferon product; and intravenous (IV), oral,
   or intrathecal corticosteroids for the purposes of disease modification.

   - Treatment with the following within 1 year prior to Screening: cyclophosphamide or

Ages Eligible for Study

18 Years - 65 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting