Trial Search Results
A Center Based Study of Pivotal Response Treatment for Preschoolers With Autism
The purpose of this study is to examine the effectiveness of pivotal response training (PRT) in an intensive center-based environment to treat social communication deficits in children with autism spectrum disorder (ASD).
Stanford is currently accepting patients for this trial.
Collaborator: John & Marcia Goldman Foundation
- Behavioral: Intensive Center-Based Pivotal Response Treatment (PRT-C)
- Diagnosis of Autism Spectrum Disorder (ASD) based on clinical interview and Diagnostic
and Statistical Manual, 5th edition (DSM-5) and confirmed using the Autism Diagnostic
Interview Revised (ADI-R) and Autism Diagnostic Observation Schedule, 2nd edition
(ADOS-2) or Childhood Autism Rating Scale (CARS-2); Diagnostic and Statistical Manual,
5th edition (DSM-5), and expert clinical opinion
- Boys and girls between 2 years and 3 years and 11 months
- Ability to participate in the testing procedures to the extent that valid standard
scores can be obtained
- Stable treatment (e.g., applied behavior analysis (ABA), speech therapy, psychotropic
medication(s) or biomedical intervention(s) for at least 1 month prior to baseline
measurements with no anticipated changes during study participation
- Developmentally delayed with Mullen Scales of Early Learning (MSEL) or Developmental
Profile (DP-4) composite score below 85 (1 Standard Deviation below the mean)
- Availability of at least one English-speaking parent who can consistently participate
in parent training and research measures.
- Current or lifetime diagnosis of severe psychiatric disorder (e.g., bipolar disorder,
- Presence of active medical problem (e.g., unstable seizure disorder or heart disease)
- Child primary language other than English
- Previous adequate trial of Pivotal Response Treatment
- More than 15 hours per week of in-home applied behavior analysis (ABA).
Ages Eligible for Study
2 Years - 3 Years
Genders Eligible for Study