Trial Search Results
The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI
The purpose of this study is to integrate advanced computational techniques and multimodal neuroimaging methods to examine the potential effects of long-term, multi-domain, online, computerized cognitive training on large-scale structural and functional brain networks in older adults with mild cognitive impairment (MCI).
Stanford is currently accepting patients for this trial.
Collaborator: National Institute on Aging (NIA)
- Behavioral: Multi-domain cognitive training
- Behavioral: Cross-word puzzle training
- Cognitive concern by subject, informant or physician
- Impairment in memory domain (delayed recall of one paragraph from Logical Memory II
subscale from Wechsler memory Scale - Revised with cutoff scores of <=8, <=4 and <=2
for 16, 8-15 and 0-7 years of education)
- Essentially normal functional activities
- Mini-Mental State Examination (MMSE) scores >=24
- Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension
medication, etc.) for at least two months.
- Any significant neurological condition including probable dementia, Parkinson's
disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.
- Presence of Axis I disorder
- Current use of psychoactive medications except for the permitted medications.
- MRI contraindication
- Any significant systemic or unstable medical condition which could lead to difficulty
complying with the protocol.
Ages Eligible for Study
65 Years - 85 Years
Genders Eligible for Study