Trial Search Results
rTMS for Orthopaedic Trauma Patients
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for orthopaedic trauma patients. In this open label study, all participants will receive accelerated theta-burst stimulation. This study will examine whether symptoms of psychiatric distress and opioid use in orthopaedic trauma patients can be mitigated with rTMS to improve post-injury recovery.
Stanford is currently accepting patients for this trial.
- Device: Accelerated intermittent theta burst treatment
- Male or female, 18 to 65 years of age.
- Able to provide informed consent.
- Present to Stanford Emergency Department as a trauma with a major operative lower
- Glasgow coma scale of 15 within 24 hours after admission or extubation
- Negative urinary toxicology screen for illicit substances;
- Negative pregnancy test if female and less then 60 y/o;
- No suspicion for a head injury and/or negative head CT scan for intracranial
hemorrhage or injury based on standard of care
- No history of seizure disorder or other neurological disorders.
- All patients included must screen positive for PHQ-9 score >4 (positive symptoms of
depression) and CES-T score <36 (poor coping self-efficacy).
- Pregnant females,
- Prior psychotic disorder,
- Current use of anti-depressant or anti-psychotic medications,
- Prior-admission opioid use within 30 days (patients will be screened for recent
prescription opioid use using the CURES report),
- Heavy alcohol use,
- Lesional neurological disorder or brain implant or intracranial ferromagnetic
- Seizure disorder
Ages Eligible for Study
18 Years - 65 Years
Genders Eligible for Study