©2024 Stanford Medicine
rTMS for Orthopaedic Trauma Patients
Not Recruiting
Trial ID: NCT03924024
Purpose
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial
magnetic stimulation device for orthopaedic trauma patients. In this open label study, all
participants will receive accelerated theta-burst stimulation. This study will examine
whether symptoms of psychiatric distress and opioid use in orthopaedic trauma patients can be
mitigated with rTMS to improve post-injury recovery.
Official Title
Repetitive Transcranial Magnetic Stimulation (rTMS) for Orthopaedic Trauma Patients
Stanford Investigator(s)
Nolan Williams
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)
Eligibility
Inclusion Criteria:
- Male or female, 18 to 65 years of age.
- Able to provide informed consent.
- Present to Stanford Emergency Department as a trauma with a major operative lower
extremity injury
- Glasgow coma scale of 15 within 24 hours after admission or extubation
- Negative urinary toxicology screen for illicit substances;
- Negative pregnancy test if female and less then 60 y/o;
- No suspicion for a head injury and/or negative head CT scan for intracranial
hemorrhage or injury based on standard of care
- No history of seizure disorder or other neurological disorders.
- All patients included must screen positive for PHQ-9 score >4 (positive symptoms of
depression) and CES-T score <36 (poor coping self-efficacy).
Exclusion Criteria:
- Incarceration,
- Pregnant females,
- Prior psychotic disorder,
- Current use of anti-depressant or anti-psychotic medications,
- Prior-admission opioid use within 30 days (patients will be screened for recent
prescription opioid use using the CURES report),
- Heavy alcohol use,
- Lesional neurological disorder or brain implant or intracranial ferromagnetic
material,
- Seizure disorder
Intervention(s):
device: Accelerated intermittent theta burst treatment
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Romina Nejad, MSc
650-497-3933