Trial Search Results
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
To initiate a low-carbohydrate, high-fat (LCHF) or ketogenic dietary (KD) intervention among a cohort of outpatients with either schizophrenia or bipolar illness who also have metabolic abnormalities, overweight/obesity, and/or are currently taking psychotropic medications experiencing metabolic side effects.
Stanford is currently not accepting patients for this trial.
- Other: LCHF, Ketogenic Diet
1. Age 18-75 years old
2. Meet DSM V criteria for schizophrenia or bipolar disorder, any subtype, for > 1 year
and clinically stable (with no hospitalization for past 3 months)
3. Currently taking psychotropic medication and gained at least 5% weight since starting
medication or have a BMI greater than or equal to 26 kg/m2 or presence of at least one
metabolic abnormality (hypertriglyceridemia, insulin resistance, dyslipidemia,
impaired glucose tolerance)
4. Willing to consent to all study procedures and attend follow-up appointments and
motivated to follow the dietary program.
5. Sufficient control over their food intake to adhere to study diets.
6. Willingness to regularly monitor blood pressure, glucose, dietary intake, and body
weight over the 4-month trial
1. Any subject pregnant or nursing
2. Comorbidity of developmental delay
3. Active substance abuse with illicit drugs or alcohol
4. In a current severe mood or psychotic state when entering the study that would
prohibit compliance with study visits or dietary program.
5. Anyone who has been hospitalized or taken clozapine over the past 3 months
6. Inability to complete baseline measurements
7. Severe renal or hepatic insufficiency
8. Cardiovascular dysfunction, including diagnosis of:
1. Congestive heart failure
5. Valvular heart disease
9. Any other medical condition that may make either diet dangerous as determined by the
study medical team (e.g. anorexia nervosa)
Ages Eligible for Study
18 Years - 75 Years
Genders Eligible for Study