A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty

Inclusion Criteria:

   - Men and women 50-85 years of age scheduled to undergo primary total hip or knee
   replacement surgery.

   - Estimated glomerular filtration rate ≥ 45 mL/min/1.73 m2 .

Exclusion Criteria:

   - Blood coagulation disorders.

   - Participants who started chronic anticoagulant therapy (warfarin, heparin,
   low-molecular weight heparin, or Factor Xa inhibitors) in the last 6 months

   - Hypercoagulable state.

   - Prior hypersensitivity to any human blood product including plasma.

   - Treatment with any human blood product, including transfusions and IV immunoglobulin,
   during the 6 months prior to screening.

   - History of immunoglobulin A or haptoglobin deficiency.

   - Major surgery, trauma or injury in the last 3 months or minor surgery in the last 1
   month.

   - Heart disease or congestive heart failure in the 6 months prior to dosing.

   - Poorly controlled hypertension.

   - Severe anemia.

   - Functional impairment of major joint or lower extremity other than joint undergoing
   surgery.